Difference between revisions of "CheC"

From SubtiWiki
Jump to: navigation, search
Line 1: Line 1:
* '''Description:''' [[CheY]]-P phosphatase, inhibition of [[CheR]]-mediated methylation of MCPs <br/><br/>
+
* '''Description:''' control of chemotaxis by interacting with [[CheD]], [[CheY]]-P phosphatase, inhibition of [[CheR]]-mediated methylation of MCPs <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
Line 68: Line 68:
 
=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:''' [[CheY]] phosphatase, [[CheD]] regulation
+
* '''Catalyzed reaction/ biological activity:'''  
 +
** [[CheY]]-P phosphatase
 +
** controls binding of [[CheD]] to chemoreceptors in response to the levels of [[CheY]]-P {{PubMed|23226535}}
  
 
* '''Protein family:''' cheC family (according to Swiss-Prot)
 
* '''Protein family:''' cheC family (according to Swiss-Prot)
Line 89: Line 91:
 
** [[McpB]]-[[CheC]] {{PubMed|11722727}}
 
** [[McpB]]-[[CheC]] {{PubMed|11722727}}
 
** [[CheA]]-[[CheC]] {{PubMed|11722727}}
 
** [[CheA]]-[[CheC]] {{PubMed|11722727}}
** [[CheC]]-[[CheD]] {{PubMed|17908686}}
+
** [[CheC]]-[[CheD]] {{PubMed|17908686}}, this interaction is enhanced by [[CheY]]-P {{PubMed|23226535}}
 
** [[CheC]]-[[CheY]]-P
 
** [[CheC]]-[[CheY]]-P
  
Line 148: Line 150:
  
 
=References=
 
=References=
<pubmed>7893679,14993307,18774298,8866475,18990184,17908686,14749334,11722727,9194713, 14651647, 9657996,8157612, 15175317,17609139, 16469702, 20080618,17675386,20133180 17850253 21515776</pubmed>
+
<pubmed>7893679,14993307,18774298,8866475,18990184,17908686,14749334,11722727,9194713, 14651647, 9657996,8157612, 15175317,17609139, 16469702, 20080618,17675386,20133180 17850253 21515776 23226535 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 14:53, 3 January 2013

  • Description: control of chemotaxis by interacting with CheD, CheY-P phosphatase, inhibition of CheR-mediated methylation of MCPs

Gene name cheC
Synonyms ylxJ
Essential no
Product CheY-P phosphatase
Function motility and chemotaxis
Gene expression levels in SubtiExpress: cheC
Interactions involving this protein in SubtInteract: CheC
MW, pI 22 kDa, 4.035
Gene length, protein length 627 bp, 209 aa
Immediate neighbours cheW, cheD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CheC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CheC expression.png















Categories containing this gene/protein

protein modification, motility and chemotaxis

This gene is a member of the following regulons

CodY regulon, SigD regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU16450

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • CheY-P phosphatase
    • controls binding of CheD to chemoreceptors in response to the levels of CheY-P PubMed
  • Protein family: cheC family (according to Swiss-Prot)
  • Paralogous protein(s):FliY

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: interaction with CheD enhances phosphatase activity towards CheY-P PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:
    • in minimal medium, CheC is present with 770 +/- 330 molecules per cell PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References