Difference between revisions of "HutM"

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== Reviews ==
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<pubmed> 22933560 </pubmed>
  
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[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 13:08, 31 August 2012

  • Description: histidine permease

Gene name hutM
Synonyms
Essential no
Product histidine permease
Function histidine uptake
Gene expression levels in SubtiExpress: hutM
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 51 kDa, 9.007
Gene length, protein length 1425 bp, 475 aa
Immediate neighbours hutG, pdp
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HutM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HutM expression.png



















Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of amino acids, utilization of amino acids, membrane proteins

This gene is a member of the following regulons

CcpA regulon, CodY regulon, HutP regulon

The gene

Basic information

  • Locus tag: BSU39390

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: amino acid-polyamine-organocation (APC) superfamily (according to Swiss-Prot)
  • Paralogous protein(s): YbgF

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (CcpA) PubMed
    • induced by histidine (HutP) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Robert A Bender
Regulation of the histidine utilization (hut) system in bacteria.
Microbiol Mol Biol Rev: 2012, 76(3);565-84
[PubMed:22933560] [WorldCat.org] [DOI] (I p)


Original publications