Difference between revisions of "UppS"
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yluA '' | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yluA '' | ||
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| − | |style="background:#ABCDEF;" align="center"| '''Essential''' || | + | |style="background:#ABCDEF;" align="center"| '''Essential''' || yes {{PubMed|22904278}} |
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|style="background:#ABCDEF;" align="center"| '''Product''' || undecaprenyl pyrophosphate synthetase | |style="background:#ABCDEF;" align="center"| '''Product''' || undecaprenyl pyrophosphate synthetase | ||
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[cell wall synthesis]]}}, | {{SubtiWiki category|[[cell wall synthesis]]}}, | ||
| − | {{SubtiWiki category|[[biosynthesis of lipids]]}} | + | {{SubtiWiki category|[[biosynthesis of lipids]]}}, |
| + | {{SubtiWiki category|[[essential genes]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| Line 51: | Line 52: | ||
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | * essential {{PubMed|22904278}} | |
| − | === Database entries === | + | * the ''[[uppS86]]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin {{PubMed|22904278}}=== Database entries === |
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
Revision as of 15:47, 22 August 2012
- Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
| Gene name | uppS |
| Synonyms | yluA |
| Essential | yes PubMed |
| Product | undecaprenyl pyrophosphate synthetase |
| Function | cell wall biosynthesis |
| Gene expression levels in SubtiExpress: uppS | |
| MW, pI | 29 kDa, 5.408 |
| Gene length, protein length | 780 bp, 260 aa |
| Immediate neighbours | frr, cdsA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis of lipids, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16530
Phenotypes of a mutant
- essential PubMed
- the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed=== Database entries ===
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
- Protein family: UPP synthetase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O31751
- KEGG entry: [2]
- E.C. number: 2.5.1.31
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Takashi Inaoka, Kozo Ochi
Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.
J Bacteriol: 2012, 194(20);5632-7
[PubMed:22904278]
[WorldCat.org]
[DOI]
(I p)
