Difference between revisions of "BdbB"

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* '''Description:''' thiol-disulfide oxidoreductase <br/><br/>
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{| align="right" border="1" cellpadding="2"
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|-
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|style="background:#ABCDEF;" align="center"|'''Gene name'''
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|''bdbB''
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|-
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yolK ''
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|-
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no
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|-
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|style="background:#ABCDEF;" align="center"| '''Product''' || thiol-disulfide oxidoreductase
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|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || oxidative folding of proteins
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|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU21440 bdbB]
 +
|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
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|-
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 9.415  
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|-
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 444 bp, 148 aa
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|-
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bhlB]]'', ''[[sunS]]''
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|-
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14062&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
 +
|-
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|colspan="2" | '''Genetic context''' <br/> [[Image:bdbB_context.gif]]
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<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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|-
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbB_2265225_2265671_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:bdbB_expression.png|500px]]
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|-
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|}
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 +
__TOC__
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
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<br/><br/><br/><br/>
 +
<br/><br/><br/><br/>
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 +
 
 +
<br/><br/>
 +
 
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= [[Categories]] containing this gene/protein =
 +
{{SubtiWiki category|[[chaperones/ protein folding]]}},
 +
{{SubtiWiki category|[[SP-beta prophage]]}},
 +
{{SubtiWiki category|[[membrane proteins]]}}
 +
 
 +
= This gene is a member of the following [[regulons]] =
 +
{{SubtiWiki regulon|[[Abh regulon]]}},
 +
{{SubtiWiki regulon|[[AbrB regulon]]}},
 +
{{SubtiWiki regulon|[[Rok regulon]]}},
 +
{{SubtiWiki regulon|[[YvrHb regulon]]}}
 +
 
 +
=The gene=
 +
 
 +
=== Basic information ===
 +
 
 +
* '''Locus tag:''' BSU21440
 +
 
 +
===Phenotypes of a mutant ===
 +
 
 +
=== Database entries ===
 +
 
 +
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunT-bdbA-yolJ-bdbB.html]
 +
 
 +
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13587]
 +
 
 +
=== Additional information===
 +
 
 +
 
 +
 
 +
 
 +
=The protein=
 +
 
 +
=== Basic information/ Evolution ===
 +
 
 +
* '''Catalyzed reaction/ biological activity:'''
 +
** oxidative folding of [[SunA]] (together with [[BdbC]])
 +
 
 +
* '''Protein family:''' NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)
 +
 
 +
* '''Paralogous protein(s):'''
 +
 
 +
=== Extended information on the protein ===
 +
 
 +
* '''Kinetic information:'''
 +
 
 +
* '''Domains:'''
 +
 
 +
* '''Modification:'''
 +
 
 +
* '''Cofactor(s):'''
 +
 
 +
* '''Effectors of protein activity:'''
 +
 
 +
* '''[[SubtInteract|Interactions]]:'''
 +
 
 +
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
 +
 
 +
=== Database entries ===
 +
 
 +
* '''Structure:'''
 +
 
 +
* '''UniProt:''' [http://www.uniprot.org/uniprot/P68571 P68571]
 +
 
 +
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21440]
 +
 
 +
* '''E.C. number:'''
 +
 
 +
=== Additional information===
 +
 
 +
=Expression and regulation=
 +
 
 +
** '''Operon:''' ''[[sunT]]-[[bdbA]]-[[sunS]]-[[bdbB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
 +
 
 +
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbB_2265225_2265671_-1 bdbB] {{PubMed|22383849}}
 +
 
 +
* '''Sigma factor:'''
 +
 
 +
* '''Regulation:'''
 +
** repressed by [[Rok]] [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed]
 +
 
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* '''Regulatory mechanism:'''
 +
** activated by [[YvrHb]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed]
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** [[Rok]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed]
 +
** [[AbrB]]: transcription repression{{PubMed|20817675}}
 +
** [[Abh]]: transcription activation {{PubMed|20817675}}
 +
 
 +
* '''Additional information:'''
 +
 
 +
=Biological materials =
 +
 
 +
* '''Mutant:'''
 +
 
 +
* '''Expression vector:'''
 +
       
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* '''lacZ fusion:'''
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* '''GFP fusion:'''
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* '''two-hybrid system:'''
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* '''Antibody:'''
 +
 
 +
=Labs working on this gene/protein=
 +
 
 +
=Your additional remarks=
 +
 
 +
=References=
 +
'''Additional publications:''' {{PubMed|20817675}}
 +
<pubmed>11872755 15743949, </pubmed>
 +
 
 +
[[Category:Protein-coding genes]]

Revision as of 20:14, 8 August 2012

  • Description: thiol-disulfide oxidoreductase

Gene name bdbB
Synonyms yolK
Essential no
Product thiol-disulfide oxidoreductase
Function oxidative folding of proteins
Gene expression levels in SubtiExpress: bdbB
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 16 kDa, 9.415
Gene length, protein length 444 bp, 148 aa
Immediate neighbours bhlB, sunS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
BdbB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BdbB expression.png
























Categories containing this gene/protein

chaperones/ protein folding, SP-beta prophage, membrane proteins

This gene is a member of the following regulons

Abh regulon, AbrB regulon, Rok regulon, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU21440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • oxidative folding of SunA (together with BdbC)
  • Protein family: NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed