YtpQ

• Description: unknown
  
  

Gene name	ytpQ
Synonyms
Essential	no
Product	unknown
Function	maybe involved in iron homeostasis
Gene expression levels in SubtiExpress: ytpQ
MW, pI	30 kDa, 5.3
Gene length, protein length	807 bp, 269 aa
Immediate neighbours	ytpR, ytpP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

acquisition of iron, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

Spx regulon

The gene

Basic information

• Locus tag: BSU29830

Phenotypes of a mutant

• derepression of the Fur and PerR regulons PubMed
• elevated oxidative protein damage upon exposure of the cells to methylglyoxal PubMed
• the spx ytpQ doulbe mutant shows reduced growth in minimal medium and hypersensitivity to methylglyoxal PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: UPF0354 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34496

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ytpP-ytpQ-ytpR PubMed

• Expression browser: ytpQ PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • Spx: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Peter Zuber, Shefali Chauhan, Praseeda Pilaka, Michiko M Nakano, Sairam Gurumoorthy, Ann A Lin, Skye M Barendt, Bui Khanh Chi, Haike Antelmann, Ulrike Mäder
Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis.
PLoS One: 2011, 6(9);e25066
[PubMed:21949854] [WorldCat.org] [DOI] (I p)