AroA

• Description: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase / chorismate mutase-isozyme 3
  
  

Gene name	aroA
Synonyms	aroG
Essential	no
Product	3-deoxy-D-arabino-heptulosonate 7-phosphate synthase / chorismate mutase-isozyme 3
Function	biosynthesis of aromatic amino acids
Gene expression levels in SubtiExpress: aroA
Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp
MW, pI	39 kDa, 5.341
Gene length, protein length	1074 bp, 358 aa
Immediate neighbours	ccpA, ytxJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, phosphoproteins

The gene

Basic information

• Locus tag: BSU29750

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Phosphoenolpyruvate + D-erythrose 4-phosphate + H₂O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate (according to Swiss-Prot)

• Protein family: class-I DAHP synthetase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylation on Ser-2 PubMed
  • phosphorylation on Thr-4 PubMed
  • phosphorylated on Arg-45 and Arg-301 PubMed

• Cofactor(s):

• Effectors of protein activity: subject to feedback inhibition PubMed

• Interactions:

• Localization:

Database entries

• Structure: 1VR6 (from Thermotoga maritima, 51% identity, 68% similarity)

• UniProt: P39912

• KEGG entry: [3]

• E.C. number: 2.5.1.54 5 and 5.4.99.5

Expression and regulation

• Operon: aroA PubMed

• Expression browser: aroA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: subject to feedback inhibition PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: