Difference between revisions of "MntH"
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|style="background:#ABCDEF;" align="center"|'''Function''' || manganese uptake | |style="background:#ABCDEF;" align="center"|'''Function''' || manganese uptake | ||
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| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU04360 mntH] | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:mntH_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:mntH_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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| + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mntH_491147_492424_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mntH_expression.png|500px]] | ||
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* '''Operon:''' ''mntH'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | * '''Operon:''' ''mntH'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ||
| − | * '''[ | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mntH_491147_492424_-1 mntH] {{PubMed|22383849}} |
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| + | * '''Sigma factor:''' | ||
* '''Regulation:''' repressed by Mn(2+) ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | * '''Regulation:''' repressed by Mn(2+) ([[MntR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ||
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** [[MntR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ** [[MntR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10760146 PubMed] | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 11:47, 7 August 2012
| Gene name | mntH |
| Synonyms | ydaR |
| Essential | no |
| Product | manganese transporter (proton symport)) |
| Function | manganese uptake |
| Gene expression levels in SubtiExpress: mntH | |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 45 kDa, 9.889 |
| Gene length, protein length | 1275 bp, 425 aa |
| Immediate neighbours | ydzK, ydaS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU04360
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: NRAMP family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P96593
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: mntH PubMed
- Sigma factor:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Emmanuel Guedon, Charles M Moore, Qiang Que, Tao Wang, Rick W Ye, John D Helmann
The global transcriptional response of Bacillus subtilis to manganese involves the MntR, Fur, TnrA and sigmaB regulons.
Mol Microbiol: 2003, 49(6);1477-91
[PubMed:12950915]
[WorldCat.org]
[DOI]
(P p)
Q Que, J D Helmann
Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins.
Mol Microbiol: 2000, 35(6);1454-68
[PubMed:10760146]
[WorldCat.org]
[DOI]
(P p)
