Difference between revisions of "CheW"

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(Expression and regulation)
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|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[CheA]] activity
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[CheA]] activity
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU16440 cheW]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 4.422   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 4.422   

Revision as of 09:47, 7 August 2012

  • Description: modulation of CheA activity in response to attractants, scaffold protein: facilitates coupling between CheA and receptors

Gene name cheW
Synonyms
Essential no
Product CheA modulator
Function control of CheA activity
Gene expression levels in SubtiExpress: cheW
MW, pI 17 kDa, 4.422
Gene length, protein length 468 bp, 156 aa
Immediate neighbours cheA, cheC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CheW context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CheW expression.png
























Categories containing this gene/protein

motility and chemotaxis

This gene is a member of the following regulons

CodY regulon, SigD regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU16440

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): CheV (N-terminal domain)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • cytoplasm (according to Swiss-Prot)
    • predominantly present at the cell poles PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:
    • subject to Clp-dependent proteolysis upon glucose starvation PubMed
    • in minimal medium, CheW is present with 2,100 +/- 430 molecules per cell PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Gerald L Hazelbauer, Wing-Cheung Lai
Bacterial chemoreceptors: providing enhanced features to two-component signaling.
Curr Opin Microbiol: 2010, 13(2);124-32
[PubMed:20122866] [WorldCat.org] [DOI] (I p)

Original publications