Difference between revisions of "SigW"
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| − | + | * '''Description:''' [[RNA polymerase]] ECF-type [[sigma factor]] SigW, activated by alkaline shock and by polymyxin B, vancomycin, cephalosporin C, D-cycloserine, and triton X-100 <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || resistance against [[SdpC]] <br/>that functions in detoxification and/or <br/>production of antimicrobial compounds | |style="background:#ABCDEF;" align="center"|'''Function''' || resistance against [[SdpC]] <br/>that functions in detoxification and/or <br/>production of antimicrobial compounds | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/SigW SigW] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/SigW SigW] | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:sigW_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:sigW_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
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* '''Operon:''' ''[[sigW]]-[[rsiW]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12207695 PubMed] | * '''Operon:''' ''[[sigW]]-[[rsiW]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12207695 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigW]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12207695 PubMed] |
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* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 09:27, 7 August 2012
- Description: RNA polymerase ECF-type sigma factor SigW, activated by alkaline shock and by polymyxin B, vancomycin, cephalosporin C, D-cycloserine, and triton X-100
| Gene name | sigW |
| Synonyms | ybbL |
| Essential | no |
| Product | RNA polymerase ECF-type sigma factor SigW |
| Function | resistance against SdpC that functions in detoxification and/or production of antimicrobial compounds |
| Interactions involving this protein in SubtInteract: SigW | |
| MW, pI | 21 kDa, 8.614 |
| Gene length, protein length | 561 bp, 187 aa |
| Immediate neighbours | trnSL-Gln2, ybbM |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
transcription, sigma factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y)
This gene is a member of the following regulons
The SigW regulon
The gene
Basic information
- Locus tag: BSU01730
Phenotypes of a mutant
- sensitive to ß-lactam antibiotics such as cefuroxime and to fosfomycin PubMed
- Inactivation of alsR, sigD and sigW increases competitive fitness of Bacillus subtilis under non-sporulating conditions PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
- A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ECF subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: RsiW acts as antagonist of SigW (anti-SigW)
Database entries
- Structure:
- UniProt: Q45585
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Thomas Wiegert, University of Bayreuth, Germany Homepage
Your additional remarks
References
Reviews
Additional reviews: PubMed
The SigW regulon
Other original publications
Additional original publications: PubMed
