Difference between revisions of "QoxC"

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Revision as of 11:47, 23 April 2012

  • Description: cytochrome aa3 quinol oxidase (subunit III)

Gene name qoxC
Synonyms ipa-39d
Essential no
Product cytochrome aa3 quinol oxidase (subunit III)
Function respiration
MW, pI 22 kDa, 6.242
Gene length, protein length 612 bp, 204 aa
Immediate neighbours qoxD, qoxB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
QoxC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
QoxC expression.png
























Categories containing this gene/protein

respiration, membrane proteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

  • Locus tag: BSU38150

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Ubiquinol-8 + O2 = Ubiquinone-8 + H2O (according to Swiss-Prot)
  • Protein family: cytochrome c oxidase subunit 3 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Sophia M Yi, Kuppala V Narasimhulu, Rimma I Samoilova, Robert B Gennis, Sergei A Dikanov
Characterization of the semiquinone radical stabilized by the cytochrome aa3-600 menaquinol oxidase of Bacillus subtilis.
J Biol Chem: 2010, 285(24);18241-51
[PubMed:20351111] [WorldCat.org] [DOI] (I p)

L Winstedt, C von Wachenfeldt
Terminal oxidases of Bacillus subtilis strain 168: one quinol oxidase, cytochrome aa(3) or cytochrome bd, is required for aerobic growth.
J Bacteriol: 2000, 182(23);6557-64
[PubMed:11073895] [WorldCat.org] [DOI] (P p)

N Azarkina, S Siletsky, V Borisov, C von Wachenfeldt, L Hederstedt, A A Konstantinov
A cytochrome bb'-type quinol oxidase in Bacillus subtilis strain 168.
J Biol Chem: 1999, 274(46);32810-7
[PubMed:10551842] [WorldCat.org] [DOI] (P p)

M Santana, F Kunst, M F Hullo, G Rapoport, A Danchin, P Glaser
Molecular cloning, sequencing, and physiological characterization of the qox operon from Bacillus subtilis encoding the aa3-600 quinol oxidase.
J Biol Chem: 1992, 267(15);10225-31
[PubMed:1316894] [WorldCat.org] (P p)