TcyM

• Description: cystine ABC transporter (permease)
  
  

Gene name	tcyM
Synonyms	ytmM
Essential	no
Product	cystine ABC transporter (permease)
Function	cystine uptake
Interactions involving this protein in SubtInteract: TcyM
Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD
MW, pI	25 kDa, 8.767
Gene length, protein length	705 bp, 235 aa
Immediate neighbours	tcyN, tcyL
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

CymR regulon, YtlI regulon

The gene

Basic information

• Locus tag: BSU29350

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: binding-protein-dependent transport system permease family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • TcyN-(TcyL-TcyM)-(TcyJ-TcyK) PubMed

• Localization:
  • cell membrane PubMed

Database entries

• Structure:

• UniProt: O34931

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytmI-tcyJ-tcyK-tcyL-tcyM-tcyN-ytmO-ytnI-ytnJ-ribR-ytnL-ytnM PubMed

• Expression browser: tcyM PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of cysteine (CymR) PubMed

• Regulatory mechanism:
  • CymR: transcription repression PubMed
  • YtlI: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed