SpoVAF

• Description: essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2+) into developing spores, required for spore maturation
  
  

Gene name	spoVAF
Synonyms
Essential	no
Product	unknown
Function	spore maturation
Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr
MW, pI	55 kDa, 6.211
Gene length, protein length	1476 bp, 492 aa
Immediate neighbours	lysA, spoVAEA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon

The gene

Basic information

• Locus tag: BSU23390

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: gerABKA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P31845

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoVAA-spoVAB-spoVAC-spoVAD-spoVAE-spoVAF-lysA PubMed

• Sigma factor: SigG PubMed

• Regulation:
  • expressed late during sporulation in the forespore (SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Your additional remarks

• Peter Setlow, University of Connecticut Health Center, USA