AcpS

• Description: acyl-carrier protein synthase, 4'-phosphopantetheine transferase
  
  

Gene name	acpS
Synonyms	ydcB
Essential	yes PubMed
Product	acyl-carrier protein synthase
Function	fatty acid biosynthesis
Interactions involving this protein in SubtInteract: AcpS
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	13 kDa, 9.915
Gene length, protein length	363 bp, 121 aa
Immediate neighbours	ydcA, ydcC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of lipids, essential genes

The gene

Basic information

• Locus tag: BSU04620

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein] (according to Swiss-Prot)

• Protein family: AcpS family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): magnesium PubMed

• Effectors of protein activity:

• Interactions:
  • AcpA-AcpS PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1F7T PubMed, 1F80 (complex with AcpA) PubMed

• UniProt: P96618

• KEGG entry: [2]

• E.C. number: 2.7.8.7

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)