GutB

• Description: D-sorbitol dehydrogenase
  
  

Gene name	gutB
Synonyms
Essential	no
Product	D-sorbitol dehydrogenase
Function	glucitol utilization
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	38 kDa, 5.213
Gene length, protein length	1059 bp, 353 aa
Immediate neighbours	gutR, gutP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

GutR regulon

The gene

Basic information

• Locus tag: BSU06150

Expression

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-iditol + NAD⁺ = L-sorbose + NADH (according to Swiss-Prot)

• Protein family: zinc-containing alcohol dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: Q06004

• KEGG entry: [3]

• E.C. number: 1.1.1.14

Expression and regulation

• Operon: gutB-gutP PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by glucitol (GutR) PubMed

• Regulatory mechanism: GutR: transcriptional activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: