Difference between revisions of "MutL"
| Line 75: | Line 75: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[MutL]] (C-terminal domain)-[[DnaN]] {{PubMed|21050827}} | + | * '''[[SubtInteract|Interactions]]:''' |
| + | ** [[MutL]] (C-terminal domain)-[[DnaN]] {{PubMed|21050827}} | ||
| + | ** [[DnaE]]-[[MutL]] {{PubMed|21958350}} | ||
| − | * '''Localization:''' | + | * '''[[Localization]]:''' |
| + | ** forms foci at midcell position, the frequency of foci increases upon mismatch formation {{PubMed|21958350}} | ||
=== Database entries === | === Database entries === | ||
| Line 123: | Line 126: | ||
=References= | =References= | ||
| − | '''Additional publications:''' {{PubMed|21050827}} | + | '''Additional publications:''' {{PubMed|21050827,21958350}} |
<pubmed>8760914, 15375129, 20603082 20525796</pubmed> | <pubmed>8760914, 15375129, 20603082 20525796</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:08, 24 October 2011
- Description: DNA mismatch repair
| Gene name | mutL |
| Synonyms | |
| Essential | no |
| Product | DNA mismatch repair |
| Function | DNA repair |
| MW, pI | 70 kDa, 5.583 |
| Gene length, protein length | 1881 bp, 627 aa |
| Immediate neighbours | mutS, ymzD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17050
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: DNA mismatch repair mutL/hexB family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- forms foci at midcell position, the frequency of foci increases upon mismatch formation PubMed
Database entries
- UniProt: P49850
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
Biological materials
- Mutant: GP1190 (del mutSL::aphA3) available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Monica C Pillon, Jessica J Lorenowicz, Michael Uckelmann, Andrew D Klocko, Ryan R Mitchell, Yu Seon Chung, Paul Modrich, Graham C Walker, Lyle A Simmons, Peter Friedhoff, Alba Guarné
Structure of the endonuclease domain of MutL: unlicensed to cut.
Mol Cell: 2010, 39(1);145-51
[PubMed:20603082]
[WorldCat.org]
[DOI]
(I p)
Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796]
[WorldCat.org]
[DOI]
(I p)
Mario Pedraza-Reyes, Ronald E Yasbin
Contribution of the mismatch DNA repair system to the generation of stationary-phase-induced mutants of Bacillus subtilis.
J Bacteriol: 2004, 186(19);6485-91
[PubMed:15375129]
[WorldCat.org]
[DOI]
(P p)
F Ginetti, M Perego, A M Albertini, A Galizzi
Bacillus subtilis mutS mutL operon: identification, nucleotide sequence and mutagenesis.
Microbiology (Reading): 1996, 142 ( Pt 8);2021-9
[PubMed:8760914]
[WorldCat.org]
[DOI]
(P p)
