IspA

• Description: intracellular serine protease
  
  

Gene name	ispA
Synonyms
Essential	no
Product	intracellular serine protease
Function	protein degradation
MW, pI	33 kDa, 4.522
Gene length, protein length	957 bp, 319 aa
Immediate neighbours	metE, rsbRB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, proteolysis

The gene

Basic information

• Locus tag: BSU13190

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase S8 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P11018

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ispA (according to DBTBS)

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Y Koide, A Nakamura, T Uozumi, T Beppu
Cloning and sequencing of the major intracellular serine protease gene of Bacillus subtilis.
J Bacteriol: 1986, 167(1);110-6
[PubMed:3087947] [WorldCat.org] [DOI] (P p)