Difference between revisions of "HmoA"
| Line 35: | Line 35: | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | {{SubtiWiki regulon|[[Fur regulon]]}} | |
=The gene= | =The gene= | ||
| Line 52: | Line 52: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| Line 60: | Line 59: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' binds hemin ''in vitro'' with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor {{PubMed|21873409}} |
* '''Protein family:''' antibiotic biosynthesis monooxygenase family (according to Swiss-Prot) | * '''Protein family:''' antibiotic biosynthesis monooxygenase family (according to Swiss-Prot) | ||
| Line 78: | Line 77: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
| − | * '''Localization:''' cytoplasm (according to Swiss-Prot) | + | * '''[[Localization]]:''' cytoplasm (according to Swiss-Prot) |
=== Database entries === | === Database entries === | ||
| Line 96: | Line 95: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[ | + | * '''Operon:''' ''[[hmoA]]'' (based on genomic context) |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced by iron limitation ([[Fur]]) {{PubMed|21873409}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[Fur]]: transcription repression {{PubMed|21873409}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
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=References= | =References= | ||
| − | + | <pubmed> 21873409</pubmed> | |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 07:12, 30 August 2011
- Description: heme monooxygenase
| Gene name | hmoA |
| Synonyms | yetG |
| Essential | no |
| Product | heme monooxygenase |
| Function | degradation of heme |
| MW, pI | 14 kDa, 9.126 |
| Gene length, protein length | 375 bp, 125 aa |
| Immediate neighbours | yetF, yetH |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU07150
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binds hemin in vitro with ~1:1 stoichiometry and degrade hemin in the presence of an electron donor PubMed
- Protein family: antibiotic biosynthesis monooxygenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O31534
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon: hmoA (based on genomic context)
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ahmed Gaballa, John D Helmann
Bacillus subtilis Fur represses one of two paralogous haem-degrading monooxygenases.
Microbiology (Reading): 2011, 157(Pt 11);3221-3231
[PubMed:21873409]
[WorldCat.org]
[DOI]
(I p)
