Difference between revisions of "GabT"

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(Extended information on the protein)
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=== Database entries ===
 
=== Database entries ===

Revision as of 19:48, 16 August 2011

  • Description: gamma-aminobutyrate transaminase, general stress protein

Gene name gabT
Synonyms ycnG
Essential no
Product gamma-aminobutyrate transaminase
Function utilization of gamma-amino butyric acid
MW, pI 47 kDa, 5.304
Gene length, protein length 1308 bp, 436 aa
Immediate neighbours gabR, gabD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GabT context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

GabR regulon

The gene

Basic information

  • Locus tag: BSU03900

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate (according to Swiss-Prot)
  • Protein family: class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed in the presence of gamma-butyric acid (GabR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)