CssR

• Description: two-component response regulator, control of cellular responses to protein secretion stress
  
  

Gene name	cssR
Synonyms	yvqA
Essential	no
Product	two-component response regulator
Function	control of cellular responses to protein secretion stress
Interactions involving this protein in SubtInteract: CssR
Metabolic function and regulation of this protein in SubtiPathways: Stress, Protein secretion
MW, pI	26 kDa, 5.071
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	htrB, cssS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, heat shock proteins, phosphoproteins

This gene is a member of the following regulons

CssR regulon

The CssR regulon:

• cssR-cssS, htrA, htrB

The gene

Basic information

• Locus tag: BSU33010

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by CssS on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions:
  • CssR interacts with the RNA polymerase PubMed
  • CssS-CssR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O32192

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cssR-cssS PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of secretion stress (CssR) PubMed

• Regulatory mechanism:
  • CssR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed