AseA

• Description: As(III) efflux pump
  
  

Gene name	aseA
Synonyms	ydfA
Essential	no
Product	As(III) efflux pump
Function	resistance to arsenite
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	47 kDa, 8.968
Gene length, protein length	1305 bp, 435 aa
Immediate neighbours	aseR, ydfB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transporters/ other, resistance against toxic metals

This gene is a member of the following regulons

AseR regulon

The gene

Basic information

• Locus tag: BSU05340

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YwrK

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P96678

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • induced by As(III) (AseR) PubMed

• Regulatory mechanism:
  • AseR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)