Difference between revisions of "RNA polymerase"

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(Important original publications: {{PubMed|20817769,20724389}})
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* [[Spx]]: transcription regulator, interacts with [[RpoA]]
 
* [[Spx]]: transcription regulator, interacts with [[RpoA]]
 
* [[MgsR]]: transcription regulator orthologous to [[Spx]], interacts with [[RpoA]]
 
* [[MgsR]]: transcription regulator orthologous to [[Spx]], interacts with [[RpoA]]
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 +
* '''Additional interaction partners of the RNA polymerase (no specific subunit specified)'''
 +
** [[HelD]], [[PcrA]], [[TopA]], [[YvqA]], [[RnhC]], [[CshA]], [[YpsC]], [[Mfd]], [[YpiA]], [[YdjO]], [[ResD]] {{PubMed|21710567}}
  
 
==Back to [[protein-protein interactions]]==
 
==Back to [[protein-protein interactions]]==
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<pubmed> 12732296 12581657 11297923 19735077 </pubmed>
 
<pubmed> 12732296 12581657 11297923 19735077 </pubmed>
 
===Important original publications: {{PubMed|20817769,20724389}} ===
 
===Important original publications: {{PubMed|20817769,20724389}} ===
<pubmed> 21350489 21515770</pubmed>
+
<pubmed> 21350489 21515770 21710567 </pubmed>

Revision as of 10:49, 29 June 2011

Parent categories
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The enzyme responsible for transcription

Components of the RNA polymerase

Core subunits

Sigma factors

  • In addition to the housekeeping sigma factor, SigA, there are several other sigma factors with different promoter recognition specifiity that are active under specific conditions (such as stress or sporulation)

Small accessory subunits

  • RpoE: delta subunit
  • YloH: omega subunit

Other interaction partners

  • NusA: essential elongation factor
  • GreA: resolve promoter proximal pausing of RNA polymerase PubMed
  • CshA

Temporary interaction partners

  • Spx: transcription regulator, interacts with RpoA
  • MgsR: transcription regulator orthologous to Spx, interacts with RpoA

Back to protein-protein interactions

References

Reviews

Finn Werner, Dina Grohmann
Evolution of multisubunit RNA polymerases in the three domains of life.
Nat Rev Microbiol: 2011, 9(2);85-98
[PubMed:21233849] [WorldCat.org] [DOI] (I p)

Vladimir Svetlov, Evgeny Nudler
Macromolecular micromovements: how RNA polymerase translocates.
Curr Opin Struct Biol: 2009, 19(6);701-7
[PubMed:19889534] [WorldCat.org] [DOI] (I p)

Evgeny Nudler
RNA polymerase active center: the molecular engine of transcription.
Annu Rev Biochem: 2009, 78;335-61
[PubMed:19489723] [WorldCat.org] [DOI] (I p)

P J Lewis, G P Doherty, J Clarke
Transcription factor dynamics.
Microbiology (Reading): 2008, 154(Pt 7);1837-1844
[PubMed:18599813] [WorldCat.org] [DOI] (P p)

Kristina M Herbert, William J Greenleaf, Steven M Block
Single-molecule studies of RNA polymerase: motoring along.
Annu Rev Biochem: 2008, 77;149-76
[PubMed:18410247] [WorldCat.org] [DOI] (P p)

Sergei Borukhov, Evgeny Nudler
RNA polymerase: the vehicle of transcription.
Trends Microbiol: 2008, 16(3);126-34
[PubMed:18280161] [WorldCat.org] [DOI] (P p)

W G Haldenwang
The sigma factors of Bacillus subtilis.
Microbiol Rev: 1995, 59(1);1-30
[PubMed:7708009] [WorldCat.org] [DOI] (P p)

The structure of RNA polymerase

Important original publications: PubMed

Olivier Delumeau, François Lecointe, Jan Muntel, Alain Guillot, Eric Guédon, Véronique Monnet, Michael Hecker, Dörte Becher, Patrice Polard, Philippe Noirot
The dynamic protein partnership of RNA polymerase in Bacillus subtilis.
Proteomics: 2011, 11(15);2992-3001
[PubMed:21710567] [WorldCat.org] [DOI] (I p)

Yoko Kusuya, Ken Kurokawa, Shu Ishikawa, Naotake Ogasawara, Taku Oshima
Transcription factor GreA contributes to resolving promoter-proximal pausing of RNA polymerase in Bacillus subtilis cells.
J Bacteriol: 2011, 193(12);3090-9
[PubMed:21515770] [WorldCat.org] [DOI] (I p)

Houra Merrikh, Cristina Machón, William H Grainger, Alan D Grossman, Panos Soultanas
Co-directional replication-transcription conflicts lead to replication restart.
Nature: 2011, 470(7335);554-7
[PubMed:21350489] [WorldCat.org] [DOI] (I p)