Ung

• Description: uracil-DNA glycosylase
  
  

Gene name	ung
Synonyms	ipa-57d, ywdG
Essential	no
Product	uracil-DNA glycosylase
Function	DNA repair
MW, pI	25 kDa, 8.782
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	ywdH, ywdF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

DNA repair/ recombination

The gene

Basic information

• Locus tag: BSU37970

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: removes uracil preferentially from single-stranded DNA over double-stranded DNA, exhibiting higher preference for U:G than U:A mismatches PubMed

• Protein family: uracil-DNA glycosylase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SsbA-Ung PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3A7N (from Mycobacterium tuberculosis, 42% identity) PubMed

• UniProt: P39615

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ung PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Prem Singh Kaushal, Ramappa K Talawar, Umesh Varshney, M Vijayan
Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2010, 66(Pt 8);887-92
[PubMed:20693660] [WorldCat.org] [DOI] (I p)

E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933] [WorldCat.org] [DOI] (P p)