Difference between revisions of "SepF"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
| − | + | ** SepF assembles into very large (∼50 nm diameter) rings. These rings are able to bundle [[FtsZ]] protofilaments into strikingly long and regular tubular structures reminiscent of eukaryotic microtubules {{PubMed|21224850}} | |
* '''Protein family:''' sepF family (according to Swiss-Prot) | * '''Protein family:''' sepF family (according to Swiss-Prot) | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[SepF]]-[[FtsZ]] | + | * '''Interactions:''' [[SepF]]-[[FtsZ]] {{PubMed|16420366}} |
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* '''Localization:''' septum {{PubMed|16420366}} | * '''Localization:''' septum {{PubMed|16420366}} | ||
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==Original Publications== | ==Original Publications== | ||
| + | '''Additional publications:''' {{PubMed|21224850}} | ||
<pubmed>16420366,16796675,14651647, </pubmed> | <pubmed>16420366,16796675,14651647, </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 11:50, 19 February 2011
- Description: part of the divisome
| Gene name | sepF |
| Synonyms | ylmF |
| Essential | no |
| Product | FtsZ-interacting protein |
| Function | proper execution of septum synthesis |
| MW, pI | 17 kDa, 4.863 |
| Gene length, protein length | 447 bp, 149 aa |
| Immediate neighbours | ylmE, ylmG |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU15390
Phenotypes of a mutant
Less efficient cell division results in longer cells. Electron microscopy reveals strongly distorted division septa.
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: sepF family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: septum PubMed
Database entries
- Structure:
- UniProt: O31728
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Leendert Hamoen, CBCB, Newcastle University, UK
Shu Ishikawa, Nara Institute of Science and Technology, Nara, Japan
Your additional remarks
SepF mutation is synthetic lethal in combination with an ezrA mutation or an ftsA mutation.
References
Reviews
David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248]
[WorldCat.org]
[DOI]
(I p)
Original Publications
Additional publications: PubMed
