Difference between revisions of "FatR"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[electron transport/ other]]}},
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{{SubtiWiki category|[[transcription factors and their control]]}},
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{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, W, X, Y)]]}}
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= This gene is a member of the following [[regulons]] =
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{{SubtiWiki regulon|[[FatR regulon]]}},
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{{SubtiWiki regulon|[[SigM regulon]]}}
  
 
=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[electron transport/ other]]}},
 
{{SubtiWiki category|[[transcription factors and their control]]}},
 
{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, W, X, Y)]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 21:49, 8 December 2010

  • Description: transcriptional repressor of the fatR-yrhJ operon

Gene name fatR
Synonyms yrhI, bscR
Essential no
Product transcriptional repressor
of the fatR-yrhJ operon (TetR family)
Function unknown
MW, pI 22 kDa, 5.621
Gene length, protein length 582 bp, 194 aa
Immediate neighbours yrhJ, yrhH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YrhI context.gif
This image was kindly provided by SubtiList




Categories containing this gene/protein

electron transport/ other, transcription factors and their control, cell envelope stress proteins (controlled by SigM, W, X, Y)

This gene is a member of the following regulons

FatR regulon, SigM regulon

The gene

Basic information

  • Locus tag: BSU27170

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced by unsaturated fatty acids (FatR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Penny D Thackray, Anne Moir
SigM, an extracytoplasmic function sigma factor of Bacillus subtilis, is activated in response to cell wall antibiotics, ethanol, heat, acid, and superoxide stress.
J Bacteriol: 2003, 185(12);3491-8
[PubMed:12775685] [WorldCat.org] [DOI] (P p)

M C Gustafsson, C N Palmer, C R Wolf, C von Wachenfeldt
Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species.
Arch Microbiol: 2001, 176(6);459-64
[PubMed:11734890] [WorldCat.org] [DOI] (P p)

T R Lee, H P Hsu, G C Shaw
Transcriptional regulation of the Bacillus subtilis bscR-CYP102A3 operon by the BscR repressor and differential induction of cytochrome CYP102A3 expression by oleic acid and palmitate.
J Biochem: 2001, 130(4);569-74
[PubMed:11574077] [WorldCat.org] [DOI] (P p)

M C Gustafsson, C von Wachenfeldt
A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter.
FEMS Microbiol Lett: 2001, 199(2);197-202
[PubMed:11377867] [WorldCat.org] [DOI] (P p)

C N Palmer, M C Gustafsson, H Dobson, C von Wachenfeldt, C R Wolf
Adaptive responses to fatty acids are mediated by the regulated expression of cytochromes P450.
Biochem Soc Trans: 1999, 27(4);374-8
[PubMed:10917605] [WorldCat.org] [DOI] (P p)