PstA

• Description: phosphate ABC transporter (permease)
  
  

Gene name	pstA
Synonyms	yqgI, yzmD
Essential	no
Product	phosphate ABC transporter (permease)
Function	high-affinity phosphate uptake
MW, pI	31 kDa, 9.303
Gene length, protein length	882 bp, 294 aa
Immediate neighbours	pstBA, pstC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, phosphate metabolism, membrane proteins

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

• Locus tag: BSU24970

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: CysTW subfamily (according to Swiss-Prot)

• Paralogous protein(s): PstC

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: (PstBA-PstBB)-(PstA-PstC)-PstS PubMed

• Localization: membrane protein PubMed

Database entries

• Structure:

• UniProt: P46340

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: pstS-pstC-pstA-pstBA-pstBB PubMed

• Sigma factor: SigA PubMed

• Regulation: expressed under conditions of phosphate limitation (5000-fold induced) (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription activation PubMed

• Additional information:
  • mRNA processing between pstS and pstC to maintain higher concentrations of PstS relative to other components of the ABC transporter PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Marion Hulett, University of Illinois at Chicago, USA Homepage