Difference between revisions of "AccC"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[biosynthesis of lipids]]}},
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{{SubtiWiki category|[[essential genes]]}}
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= This gene is a member of the following [[regulons]] =
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=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[biosynthesis of lipids]]}},
 
{{SubtiWiki category|[[essential genes]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 21:15, 8 December 2010

  • Description: acetyl-CoA carboxylase (biotin carboxylase subunit)

Gene name accC
Synonyms yqhX
Essential yes PubMed
Product acetyl-CoA carboxylase (biotin carboxylase subunit)
Function production of malonyl-CoA, the substrate for fatty acid biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 49 kDa, 4.72
Gene length, protein length 1350 bp, 450 aa
Immediate neighbours yqhY, accB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AccC context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis of lipids, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU24340

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s): YotE

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure: 1BNC (the protein from E. coli) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)

Original Publications