Difference between revisions of "FolD"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[translation]]}},
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{{SubtiWiki category|[[essential genes]]}}
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= This gene is a member of the following [[regulons]] =
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{{SubtiWiki regulon|[[PurR regulon]]}}
  
 
=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[translation]]}},
 
{{SubtiWiki category|[[essential genes]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 21:15, 8 December 2010

  • Description: methylenetetrahydrofolate dehydrogenase (NADP)

Gene name folD
Synonyms yqiA
Essential yes PubMed
Product methylenetetrahydrofolate dehydrogenase (NADP)
Function formylation of Met-tRNA(fMet)
MW, pI 30 kDa, 5.6
Gene length, protein length 849 bp, 283 aa
Immediate neighbours yqiB, nusB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FolD context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

translation, essential genes

This gene is a member of the following regulons

PurR regulon

The gene

Basic information

  • Locus tag: BSU24310

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH (according to Swiss-Prot)
  • Protein family: tetrahydrofolate dehydrogenase/cyclohydrolase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of purine nucleotides (PurR) PubMed
  • Regulatory mechanism:
    • PurR: transcription repression (molecular inducer: PRPP) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References