Difference between revisions of "MsrA"
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| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
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| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[Spx regulon]]}} | ||
=The gene= | =The gene= | ||
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=The protein= | =The protein= | ||
Revision as of 20:38, 8 December 2010
- Description: peptide methionine sulfoxide reductase
| Gene name | msrA |
| Synonyms | yppP |
| Essential | no |
| Product | peptide methionine sulfoxide reductase |
| Function | regeneration of methionine and restoration of protein function after oxidative damage |
| MW, pI | 20 kDa, 5.709 |
| Gene length, protein length | 531 bp, 177 aa |
| Immediate neighbours | msrB, ypoP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU21690
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: P54154
- KEGG entry: [2]
- E.C. number: 1.8.4.11
Additional information
Expression and regulation
- Regulation: induced by oxidative stress (Spx)
- Regulatory mechanism: Spx: oxidized Spx binds RpoA and enhances msrA-msrB operon transcription PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
