MurC

• Description: UDP-N-acetylmuramoyl-L-alanine synthetase
  
  

Gene name	murC
Synonyms	ytxF
Essential	yes PubMed
Product	UDP-N-acetylmuramoyl-L-alanine synthetase
Function	peptidoglycan precursor biosynthesis
Metabolic function and regulation of this protein in SubtiPathways: Cell wall
MW, pI	48 kDa, 5.307
Gene length, protein length	1296 bp, 432 aa
Immediate neighbours	ytxG, sftA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU29790

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine (according to Swiss-Prot)

• Protein family: murCDEF family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot), Cytoplasm (Homogeneous) PubMed

Database entries

• Structure:

• UniProt: P40778

• KEGG entry: [3]

• E.C. number: 6.3.2.8

Expression and regulation

• Operon: murC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: