MntC

• Description: manganese ABC transporter (membrane protein)
  
  

Gene name	mntC
Synonyms	ytgC
Essential	no
Product	manganese ABC transporter (membrane protein)
Function	manganese uptake
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	47 kDa, 9.354
Gene length, protein length	1305 bp, 435 aa
Immediate neighbours	mntD, mntB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU30750

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

ABC transporters, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC-3 integral membrane protein family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: MntB-(MntC-MntD)-MntA PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O35024

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: mntA-mntB-mntC-mntD PubMed

• Sigma factor:

• Regulation:
  • repressed at high Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism:
  • MntR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage