HtpG

• Description: class III heat-shock protein (molecular chaperone)
  
  

Gene name	htpG
Synonyms	yxbB
Essential	no
Product	class III heat-shock protein (molecular chaperone)
Function	chaperone
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	72 kDa, 4.668
Gene length, protein length	1878 bp, 626 aa
Immediate neighbours	csbC, yxcA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU39820

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

chaperones/ protein folding, heat shock proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: heat shock protein 90 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 2IOQ (from Escherichia coli, 39% identity, 61% similarity) PubMed

• UniProt: P46208

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: htpG PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by high temperature PubMed

• Regulatory mechanism: unknown

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage

References

Saskia Versteeg, Angelika Escher, Andy Wende, Thomas Wiegert, Wolfgang Schumann
Regulation of the Bacillus subtilis heat shock gene htpG is under positive control.
J Bacteriol: 2003, 185(2);466-74
[PubMed:12511492] [WorldCat.org] [DOI] (P p)

S Versteeg, A Mogk, W Schumann
The Bacillus subtilis htpG gene is not involved in thermal stress management.
Mol Gen Genet: 1999, 261(3);582-8
[PubMed:10323241] [WorldCat.org] [DOI] (P p)

A Schulz, S Schwab, G Homuth, S Versteeg, W Schumann
The htpG gene of Bacillus subtilis belongs to class III heat shock genes and is under negative control.
J Bacteriol: 1997, 179(10);3103-9
[PubMed:9150201] [WorldCat.org] [DOI] (P p)