FtsE

• Description: ABC transporter (ATP-binding protein) (FtsE-FtsX), required for proper activation of Spo0A and initiation of sporulation
  
  

Gene name	ftsE
Synonyms
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	initiation of sporulation
MW, pI	25 kDa, 8.419
Gene length, protein length	684 bp, 228 aa
Immediate neighbours	ftsX, cccB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU35260

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

ABC transporters, phosphorelay, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: FtsE-FtsX PubMed

• Localization: membrane associated (via FtsX) PubMed

Database entries

• Structure:

• UniProt: O34814

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsE-ftsX (according to DBTBS)

• Sigma factor:

• Regulation:
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Sharon Garti-Levi, Ronen Hazan, James Kain, Masaya Fujita, Sigal Ben-Yehuda
The FtsEX ABC transporter directs cellular differentiation in Bacillus subtilis.
Mol Microbiol: 2008, 69(4);1018-28
[PubMed:18573177] [WorldCat.org] [DOI] (I p)

Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)