ClpQ

• Description: two-component ATP-dependent protease
  
  

Gene name	clpQ
Synonyms	hslV, codW
Essential	no
Product	two-component ATP-dependent protease
Function	protein degradation
MW, pI	19 kDa, 6.105
Gene length, protein length	543 bp, 181 aa
Immediate neighbours	codV, clpY
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU16150

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

proteolysis, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: HslV subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: ClpQ-ClpY PubMed

• Localization: cytoplasm, forms small foci, usually positioned near the cell membrane, formation of foci depends on the presence of the cognate ATPase ClpY PubMed

Database entries

• Structure: 2Z3B

• UniProt: P39070

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: codV-clpQ-clpY-codY PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: