Difference between revisions of "PsdA"
| Line 1: | Line 1: | ||
| − | * '''Description:''' | + | * '''Description:''' [[ABC transporter]] (ATP-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| − | |'' | + | |''psdA'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yvcR '' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] (ATP-binding protein) | |style="background:#ABCDEF;" align="center"| '''Product''' || [[ABC transporter]] (ATP-binding protein) | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || export of toxic peptides |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 6.345 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 6.345 | ||
| Line 18: | Line 18: | ||
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 777 bp, 259 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 777 bp, 259 aa | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[psdB]]'', ''[[psdS]]'' |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15475]+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15475]+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' | ||
| Line 70: | Line 70: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[ | + | * '''Interactions:''' [[PsdA]]-[[PsdB]] {{PubMed|10092453}} |
| − | * '''Localization:''' membrane associated (via [[ | + | * '''Localization:''' membrane associated (via [[PsdB]]) {{PubMed|10092453}} |
=== Database entries === | === Database entries === | ||
| Line 87: | Line 87: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[ | + | * '''Operon:''' |
| + | ** ''[[psdA]]-[[psdB]]'' {{PubMed|18394148}} | ||
| + | ** ''[[psdR]]-[[psdS]]-[[psdA]]-[[psdB]]'' {{PubMed|21078927}} | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| + | ** ''[[psdA]]'': [[SigA]] {{PubMed|21078927}} | ||
| + | ** ''[[psdR]]'': [[SigA]] {{PubMed|21078927}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** induced by nisin, gallidermin {{PubMed| | + | ** ''[[psdA]]'': induced by nisin, gallidermin ([[PsdR]]) {{PubMed|21078927}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[PsdR]]: transcription activation {{PubMed|21078927}} | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
| Line 118: | Line 123: | ||
=References= | =References= | ||
| − | <pubmed>18394148,10092453,, </pubmed> | + | <pubmed>18394148,10092453,21078927, </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 18:17, 17 November 2010
- Description: ABC transporter (ATP-binding protein) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin
| Gene name | psdA |
| Synonyms | yvcR |
| Essential | no |
| Product | ABC transporter (ATP-binding protein) |
| Function | export of toxic peptides |
| MW, pI | 28 kDa, 6.345 |
| Gene length, protein length | 777 bp, 259 aa |
| Immediate neighbours | psdB, psdS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU34700
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O06980
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927]
[WorldCat.org]
[DOI]
(I p)
Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148]
[WorldCat.org]
[DOI]
(I p)
Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453]
[WorldCat.org]
[DOI]
(P p)
