Difference between revisions of "BceR"

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* '''Description:''' [[two-component systems|two-component]] response regulator, regulation of ''[[bceA]]-[[bceB]]'' in response to bacitracin <br/><br/>
+
* '''Description:''' [[two-component systems|two-component]] response regulator, regulation of ''[[bceA]]-[[bceB]]'' in response to bacitracin, plectasin, mersacidin and actagardine <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator  
 
|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] response regulator  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of ''[[bceA]]-[[bceB]]'' in response to bacitracin
+
|style="background:#ABCDEF;" align="center"|'''Function''' || resistance against  toxic peptides
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 5.289   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 26 kDa, 5.289   
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=References=
 
=References=
  
<pubmed>10094672,18394148,12890034,14651641,12399481, </pubmed>
+
<pubmed>10094672,18394148,12890034,14651641,12399481, 21078927 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 17:44, 17 November 2010

  • Description: two-component response regulator, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine

Gene name bceR
Synonyms ytsA
Essential no
Product two-component response regulator
Function resistance against toxic peptides
MW, pI 26 kDa, 5.289
Gene length, protein length 693 bp, 231 aa
Immediate neighbours bceS, ytrF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YtsA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU30400

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated by BceS on an Asp residue
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Peptide antibiotic sensing and detoxification modules of Bacillus subtilis.
Antimicrob Agents Chemother: 2011, 55(2);515-25
[PubMed:21078927] [WorldCat.org] [DOI] (I p)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Thorsten Mascher, Neil G Margulis, Tao Wang, Rick W Ye, John D Helmann
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.
Mol Microbiol: 2003, 50(5);1591-604
[PubMed:14651641] [WorldCat.org] [DOI] (P p)

Reiko Ohki, Giyanto, Kozue Tateno, Waka Masuyama, Shigeki Moriya, Kazuo Kobayashi, Naotake Ogasawara
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Mol Microbiol: 2003, 49(4);1135-44
[PubMed:12890034] [WorldCat.org] [DOI] (P p)

Min Cao, John D Helmann
Regulation of the Bacillus subtilis bcrC bacitracin resistance gene by two extracytoplasmic function sigma factors.
J Bacteriol: 2002, 184(22);6123-9
[PubMed:12399481] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)