Difference between revisions of "MenD"

From SubtiWiki
Jump to: navigation, search
Line 70: Line 70:
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''Cofactor(s):''' thiamine pyrophosphate, divalent metal ion such as Mn(2+)) {{PubMed|20600129}}
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
Line 120: Line 120:
  
 
=References=
 
=References=
<pubmed>9387221,1629163,8550504 </pubmed>
+
<pubmed>9387221,1629163,8550504 20600129 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:18, 6 July 2010

  • Description: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase

Gene name menD
Synonyms
Essential yes PubMed
Product 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
synthase / 2-oxoglutarate decarboxylase
Function biosynthesis of menaquinone
Metabolic function and regulation of this protein in SubtiPathways:
Menaquinone
MW, pI 63 kDa, 5.655
Gene length, protein length 1740 bp, 580 aa
Immediate neighbours ytxM, menF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MenD context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU30820

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 (according to Swiss-Prot)
  • Protein family: MenD subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): thiamine pyrophosphate, divalent metal ion such as Mn(2+)) PubMed
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References