Difference between revisions of "SpoIIP"
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| − | * '''Description:''' required for dissolution of the septal cell wall <br/><br/> | + | * '''Description:''' cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || cell wall hydrolase |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || dissolution of the septal cell wall | |style="background:#ABCDEF;" align="center"|'''Function''' || dissolution of the septal cell wall | ||
| Line 52: | Line 52: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' removes the stem peptides from the cell wall and cleaves the cross-links between them {{PubMed|20159959}} |
* '''Protein family:''' | * '''Protein family:''' | ||
| Line 68: | Line 68: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' activity is stimulated by interaction with [[SpoIID]] {{PubMed|20159959}} |
| − | * '''Interactions:''' | + | * '''Interactions:''' [[SpoIID]]-[[SpoIIP]] {{PubMed|20159959}} |
| − | * '''Localization:''' | + | * '''Localization:''' cell membrane {{PubMed|20159959}} |
=== Database entries === | === Database entries === | ||
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=References= | =References= | ||
| − | <pubmed>16497325,17376078,15882622,11886548,15752199 , </pubmed> | + | <pubmed>16497325,17376078,15882622,11886548,15752199 , 20159959 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:10, 18 February 2010
- Description: cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall
| Gene name | spoIIP |
| Synonyms | |
| Essential | no |
| Product | cell wall hydrolase |
| Function | dissolution of the septal cell wall |
| MW, pI | 44 kDa, 6.852 |
| Gene length, protein length | 1203 bp, 401 aa |
| Immediate neighbours | yqxA, gpr |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU25530
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: removes the stem peptides from the cell wall and cleaves the cross-links between them PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Localization: cell membrane PubMed
Database entries
- Structure:
- UniProt: P37968
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Cecile Morlot, Tsuyoshi Uehara, Kathleen A Marquis, Thomas G Bernhardt, David Z Rudner
A highly coordinated cell wall degradation machine governs spore morphogenesis in Bacillus subtilis.
Genes Dev: 2010, 24(4);411-22
[PubMed:20159959]
[WorldCat.org]
[DOI]
(I p)
Arnaud Chastanet, Richard Losick
Engulfment during sporulation in Bacillus subtilis is governed by a multi-protein complex containing tandemly acting autolysins.
Mol Microbiol: 2007, 64(1);139-52
[PubMed:17376078]
[WorldCat.org]
[DOI]
(P p)
Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325]
[WorldCat.org]
[DOI]
(P p)
Jonathan Dworkin, Richard Losick
Developmental commitment in a bacterium.
Cell: 2005, 121(3);401-9
[PubMed:15882622]
[WorldCat.org]
[DOI]
(P p)
Thierry Doan, Kathleen A Marquis, David Z Rudner
Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum.
Mol Microbiol: 2005, 55(6);1767-81
[PubMed:15752199]
[WorldCat.org]
[DOI]
(P p)
P Eichenberger, P Fawcett, R Losick
A three-protein inhibitor of polar septation during sporulation in Bacillus subtilis.
Mol Microbiol: 2001, 42(5);1147-62
[PubMed:11886548]
[WorldCat.org]
[DOI]
(P p)
