PlsY

• Description: acylphosphate:glycerol-phosphate acyltransferase
  
  

Gene name	plsY
Synonyms	yneS
Essential	yes PubMed
Product	acylphosphate:glycerol-phosphate acyltransferase
Function	biosynthesis of phospholipids
Metabolic function and regulation of this protein in SubtiPathways: Fatty acid and phospholipid biosynthesis
MW, pI	20 kDa, 10.408
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	yneR, yneT
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU18070

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Acyl-phosphate + sn-glycerol 3-phosphate = acyl-sn-glycerol 3-phosphate + phosphate (according to UniProt)

• Protein family: UPF0078 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: PlsY-PlsX PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: Q45064

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Matsumoto lab PubMed

• Antibody:

References

Reviews

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)