Difference between revisions of "LmrA"
| Line 68: | Line 68: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' flavonoids such as quercetin serve as inducers, binding results in release from DNA {{PubMed|17483215}} |
* '''Interactions:''' | * '''Interactions:''' | ||
| Line 87: | Line 87: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | |||
* '''Operon:''' ''[[lmrA]]-[[lmrB]]'' {{PubMed|15317768}} | * '''Operon:''' ''[[lmrA]]-[[lmrB]]'' {{PubMed|15317768}} | ||
| Line 93: | Line 92: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced by flavonoids such as quercetin ([[LmrA]]){{PubMed|17483215}} | ||
| − | * '''Regulatory mechanism:''' [[LmrA]]: transcription repression {{PubMed|15317768}} | + | * '''Regulatory mechanism:''' |
| + | ** [[LmrA]]: transcription repression {{PubMed|15317768}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
Revision as of 17:03, 13 February 2010
| Gene name | lmrA |
| Synonyms | lin-2, yccB |
| Essential | no |
| Product | transcriptional regulator |
| Function | control of quercetin utilization |
| MW, pI | 20 kDa, 5.033 |
| Gene length, protein length | 564 bp, 188 aa |
| Immediate neighbours | lmrB, ansZ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU02680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): YxaF
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: flavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34619
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Kazutake Hirooka, Satoshi Kunikane, Hiroshi Matsuoka, Ken-Ichi Yoshida, Kanako Kumamoto, Shigeo Tojo, Yasutaro Fujita
Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids.
J Bacteriol: 2007, 189(14);5170-82
[PubMed:17483215]
[WorldCat.org]
[DOI]
(P p)
Ken-Ichi Yoshida, Yo-Hei Ohki, Makiko Murata, Masaki Kinehara, Hiroshi Matsuoka, Takenori Satomura, Reiko Ohki, Miyuki Kumano, Kunio Yamane, Yasutaro Fujita
Bacillus subtilis LmrA is a repressor of the lmrAB and yxaGH operons: identification of its binding site and functional analysis of lmrB and yxaGH.
J Bacteriol: 2004, 186(17);5640-8
[PubMed:15317768]
[WorldCat.org]
[DOI]
(P p)
Miyuki Kumano, Masaya Fujita, Kouji Nakamura, Makiko Murata, Reiko Ohki, Kunio Yamane
Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants.
Antimicrob Agents Chemother: 2003, 47(1);432-5
[PubMed:12499232]
[WorldCat.org]
[DOI]
(P p)
