Difference between revisions of "AroK"
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| − | * '''Description:''' shikimate kinase | + | * '''Description:''' shikimate kinase<br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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| − | |style="background:#ABCDEF;" align="center"| '''Product''' || shikimate kinase | + | |style="background:#ABCDEF;" align="center"| '''Product''' || shikimate kinase |
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of aromatic amino acids | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of aromatic amino acids | ||
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=References= | =References= | ||
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[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 06:19, 15 January 2010
- Description: shikimate kinase
| Gene name | aroK |
| Synonyms | aroI |
| Essential | no |
| Product | shikimate kinase |
| Function | biosynthesis of aromatic amino acids |
| Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp | |
| MW, pI | 21 kDa, 5.969 |
| Gene length, protein length | 558 bp, 186 aa |
| Immediate neighbours | tmrB, ycgJ |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU03150
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + shikimate = ADP + shikimate 3-phosphate (according to Swiss-Prot)
- Protein family: shikimate kinase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P37944
- KEGG entry: [3]
- E.C. number: 2.7.1.71
Additional information
Expression and regulation
- Operon: aroK (according to DBTBS)
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
L Huang, A L Montoya, E W Nester
Purification and characterization of shikimate kinase enzyme activity in Bacillus subtilis.
J Biol Chem: 1975, 250(19);7675-81
[PubMed:170268]
[WorldCat.org]
(P p)
J A Hoch, E W Nester
Gene-enzyme relationships of aromatic acid biosynthesis in Bacillus subtilis.
J Bacteriol: 1973, 116(1);59-66
[PubMed:4200844]
[WorldCat.org]
[DOI]
(P p)
E W Nester, R A Jensen, D S Nasser
Regulation of enzyme synthesis in the aromatic amino acid pathway of Bacillus subtilus.
J Bacteriol: 1969, 97(1);83-90
[PubMed:4974400]
[WorldCat.org]
[DOI]
(P p)
