Difference between revisions of "RNA switch"
(→List of Bacillus subtilis RNAswitches) |
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** ''[[bglS]]'', ''[[bglP]]-[[bglH]]-[[yxiE]]'': controlled by [[BglP]] | ** ''[[bglS]]'', ''[[bglP]]-[[bglH]]-[[yxiE]]'': controlled by [[BglP]] | ||
** ''[[glpD]]'', ''[[glpF]]-[[glpK]]'', ''[[glpT]]-[[glpQ]]'': controlled by [[GlpP]] | ** ''[[glpD]]'', ''[[glpF]]-[[glpK]]'', ''[[glpT]]-[[glpQ]]'': controlled by [[GlpP]] | ||
| − | ** ''[[pabA]]'', ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]'', ''[[trpP]]'', ''[[ycbK]]'': controlled by [[TRAP | + | ** ''[[pabA]]'', ''[[trpE]]-[[trpD]]-[[trpC]]-[[trpF]]-[[trpB]]-[[trpA]]'', ''[[trpP]]'', ''[[ycbK]]'': controlled by [[MtrB|TRAP]] |
** ''[[hutH]]-[[hutU]]-[[hutI]]-[[hutG]]-[[hutM]]'': controlled by [[HutP]] | ** ''[[hutH]]-[[hutU]]-[[hutI]]-[[hutG]]-[[hutM]]'': controlled by [[HutP]] | ||
** ''[[pyrR]]-[[pyrP]]-[[pyrB]]-[[pyrC]]-[[pyrAA]]-[[pyrAB]]-[[pyrK]]-[[pyrD]]-[[pyrF]]-[[pyrE]]'': [[PyrR]] | ** ''[[pyrR]]-[[pyrP]]-[[pyrB]]-[[pyrC]]-[[pyrAA]]-[[pyrAB]]-[[pyrK]]-[[pyrD]]-[[pyrF]]-[[pyrE]]'': [[PyrR]] | ||
Revision as of 20:14, 17 December 2009
RNA switches are regulatory systems that rely on alternative mRNA structures.
RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)
List of Bacillus subtilis RNAswitches
- Protein-dependent RNA switches
- L20 leader: in front of the infC-rpmI-rplT-ysdA operon: controlled by RplT binding
- ptsG-ptsH-ptsI: controlled by GlcT
- sacX-sacY, sacB: controlled by SacY
- sacP-sacA: controlled by SacT
- bglS, bglP-bglH-yxiE: controlled by BglP
- glpD, glpF-glpK, glpT-glpQ: controlled by GlpP
- pabA, trpE-trpD-trpC-trpF-trpB-trpA, trpP, ycbK: controlled by TRAP
- hutH-hutU-hutI-hutG-hutM: controlled by HutP
- pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE: PyrR
- Potential additional RNA switches
The function of these potential RNA structures is unknown. They were suggested to control the mentioned genes.
- ydaO-yuaA switch: ydaO, ktrA
- ykkC-yxkD switch: ykkC, yxkD
- yybP-ykoY switch: yybP, ykoY
- ylbH switch: ylbH
- L10 leader: rplJ
- L13 leader: rplM
- L19 leader: rplS
- L21_leader:in front of the rplU-ysxB-rpmA operon
Important Reviews
Michael D Dambach, Wade C Winkler
Expanding roles for metabolite-sensing regulatory RNAs.
Curr Opin Microbiol: 2009, 12(2);161-9
[PubMed:19250859]
[WorldCat.org]
[DOI]
(I p)
Tina M Henkin
Riboswitch RNAs: using RNA to sense cellular metabolism.
Genes Dev: 2008, 22(24);3383-90
[PubMed:19141470]
[WorldCat.org]
[DOI]
(P p)
Jesse C Cochrane, Scott A Strobel
Riboswitch effectors as protein enzyme cofactors.
RNA: 2008, 14(6);993-1002
[PubMed:18430893]
[WorldCat.org]
[DOI]
(I p)
Catherine A Wakeman, Wade C Winkler, Charles E Dann
Structural features of metabolite-sensing riboswitches.
Trends Biochem Sci: 2007, 32(9);415-24
[PubMed:17764952]
[WorldCat.org]
[DOI]
(P p)
Irnov, A Kertsburg, W C Winkler
Genetic control by cis-acting regulatory RNAs in Bacillus subtilis: general principles and prospects for discovery.
Cold Spring Harb Symp Quant Biol: 2006, 71;239-49
[PubMed:17381303]
[WorldCat.org]
[DOI]
(P p)
Frank J Grundy, Tina M Henkin
From ribosome to riboswitch: control of gene expression in bacteria by RNA structural rearrangements.
Crit Rev Biochem Mol Biol: 2006, 41(6);329-38
[PubMed:17092822]
[WorldCat.org]
[DOI]
(P p)
Wade C Winkler
Riboswitches and the role of noncoding RNAs in bacterial metabolic control.
Curr Opin Chem Biol: 2005, 9(6);594-602
[PubMed:16226486]
[WorldCat.org]
[DOI]
(P p)
Wade C Winkler, Ronald R Breaker
Regulation of bacterial gene expression by riboswitches.
Annu Rev Microbiol: 2005, 59;487-517
[PubMed:16153177]
[WorldCat.org]
[DOI]
(P p)
Wade C Winkler
Metabolic monitoring by bacterial mRNAs.
Arch Microbiol: 2005, 183(3);151-9
[PubMed:15750802]
[WorldCat.org]
[DOI]
(P p)
Frank J Grundy, Tina M Henkin
Regulation of gene expression by effectors that bind to RNA.
Curr Opin Microbiol: 2004, 7(2);126-31
[PubMed:15063848]
[WorldCat.org]
[DOI]
(P p)
Wade C Winkler, Ronald R Breaker
Genetic control by metabolite-binding riboswitches.
Chembiochem: 2003, 4(10);1024-32
[PubMed:14523920]
[WorldCat.org]
[DOI]
(P p)
