RapC

• Description: response regulator aspartate phosphatase, controls ComA activity
  
  

Gene name	rapC
Synonyms	yclL
Essential	no
Product	response regulator aspartate phosphatase
Function	control of ComA activity
MW, pI	45 kDa, 5.024
Gene length, protein length	1146 bp, 382 aa
Immediate neighbours	yclK, phrC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU03770

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: control of ComA activity PubMed

• Protein family: RAP family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: binding of PhrC to RapC prevents it from binding ComA PubMed

• Interactions: RapC-PhrC PubMed, RapC-ComA PubMed

• Localization:

Database entries

• Structure:

• UniProt: P94415

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rapC-phrC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed
  • ComA: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Leighton Core, Marta Perego
TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis.
Mol Microbiol: 2003, 49(6);1509-22
[PubMed:12950917] [WorldCat.org] [DOI] (P p)

B A Lazazzera, I G Kurtser, R S McQuade, A D Grossman
An autoregulatory circuit affecting peptide signaling in Bacillus subtilis.
J Bacteriol: 1999, 181(17);5193-200
[PubMed:10464187] [WorldCat.org] [DOI] (P p)