Noc

• Description: DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division
  
  

Gene name	noc
Synonyms	yyaA
Essential	no
Product	effector of nucleoid occlusion
Function	control of cell division
MW, pI	32 kDa, 5.812
Gene length, protein length	849 bp, 283 aa
Immediate neighbours	yyaB, rsmG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40990

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds specific sites on the chromosome PubMed

• Protein family: ParB family (according to Swiss-Prot)

• Paralogous protein(s): Spo0J

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P37524

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: thdF-gidA-rsmG-noc

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion: available in the Jeff Errington lab

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jeff Errington, Newcastle, UK Homepage

References

Reviews

Marc Bramkamp, Suey van Baarle
Division site selection in rod-shaped bacteria.
Curr Opin Microbiol: 2009, 12(6);683-8
[PubMed:19884039] [WorldCat.org] [DOI] (I p)

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)

Original Publications

Ling Juan Wu, Shu Ishikawa, Yoshikazu Kawai, Taku Oshima, Naotake Ogasawara, Jeff Errington
Noc protein binds to specific DNA sequences to coordinate cell division with chromosome segregation.
EMBO J: 2009, 28(13);1940-52
[PubMed:19494834] [WorldCat.org] [DOI] (I p)

Yoshikazu Kawai, Naotake Ogasawara
Bacillus subtilis EzrA and FtsL synergistically regulate FtsZ ring dynamics during cell division.
Microbiology (Reading): 2006, 152(Pt 4);1129-1141
[PubMed:16549676] [WorldCat.org] [DOI] (P p)

Ling Juan Wu, Jeff Errington
Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis.
Cell: 2004, 117(7);915-25
[PubMed:15210112] [WorldCat.org] [DOI] (P p)

Jörg Sievers, Brian Raether, Marta Perego, Jeff Errington
Characterization of the parB-like yyaA gene of Bacillus subtilis.
J Bacteriol: 2002, 184(4);1102-11
[PubMed:11807071] [WorldCat.org] [DOI] (P p)