Difference between revisions of "NsrR"
(→Expression and regulation) |
|||
| Line 12: | Line 12: | ||
|style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor | |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || upregulation of | + | |style="background:#ABCDEF;" align="center"|'''Function''' || upregulation of [[ResD]]-[[ResE]]-dependent genes in the presence of nitric oxide (NO) |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]''' | ||
| Line 70: | Line 70: | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' nitric oxide (NO) acts as molecular inducer and results in NsrR release from its DNA targets |
* '''Interactions:''' | * '''Interactions:''' | ||
Revision as of 21:15, 30 October 2009
- Description: nitric oxide-responsive regulator
| Gene name | nsrR |
| Synonyms | yhdE |
| Essential | no |
| Product | transcriptional repressor |
| Function | upregulation of ResD-ResE-dependent genes in the presence of nitric oxide (NO) |
| Metabolic function and regulation of this protein in SubtiPathways: Stress | |
| MW, pI | 16 kDa, 7.75 |
| Gene length, protein length | 438 bp, 146 aa |
| Immediate neighbours | lytF, ygxB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU09380
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: nitric oxide (NO) acts as molecular inducer and results in NsrR release from its DNA targets
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O07573
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: nsrR PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Erik T Yukl, Mohamed A Elbaz, Michiko M Nakano, Pierre Moënne-Loccoz
Transcription Factor NsrR from Bacillus subtilis Senses Nitric Oxide with a 4Fe-4S Cluster (†).
Biochemistry: 2008, 47(49);13084-92
[PubMed:19006327]
[WorldCat.org]
[DOI]
(I p)
Annika Rogstam, Jonas T Larsson, Peter Kjelgaard, Claes von Wachenfeldt
Mechanisms of adaptation to nitrosative stress in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3063-71
[PubMed:17293416]
[WorldCat.org]
[DOI]
(P p)
Michiko M Nakano, Hao Geng, Shunji Nakano, Kazuo Kobayashi
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
J Bacteriol: 2006, 188(16);5878-87
[PubMed:16885456]
[WorldCat.org]
[DOI]
(P p)
