Difference between revisions of "ParC"
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=Expression and regulation= | =Expression and regulation= | ||
− | * '''Operon:''' | + | * '''Operon:''' ''[[parE]]-[[parC]]'' {{PubMed|16267290}} |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
− | ** | + | ** induced by DNA damage ([[LexA]]) {{PubMed|16267290}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | ** [[LexA]]: transcription repression | + | ** [[LexA]]: transcription repression {{PubMed|16267290}} |
− | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = |
Revision as of 19:56, 18 October 2009
- Description: subunit of DNA topoisomerase IV
Gene name | parC |
Synonyms | grlA |
Essential | yes PubMed |
Product | subunit of DNA topoisomerase IV |
Function | chromosome segregation and compaction |
MW, pI | 91 kDa, 6.307 |
Gene length, protein length | 2418 bp, 806 aa |
Immediate neighbours | parE, ynfC |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context ![]() This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU18100
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: topoisomerase gyrA/parC subunit family (according to Swiss-Prot)
- Paralogous protein(s): GyrA
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot), Cytoplasm (Homogeneous) PubMed polar localization in actively growing cells PubMed
Database entries
- Structure: 1WP5 (C-terminal domain, Geobacillus stearothermophilus)
- UniProt: Q45066
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537]
[WorldCat.org]
[DOI]
(P p)
Serkalem Tadesse, Judita Mascarenhas, Bernd Kösters, Andrej Hasilik, Peter L Graumann
Genetic interaction of the SMC complex with topoisomerase IV in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 11);3729-3737
[PubMed:16272394]
[WorldCat.org]
[DOI]
(P p)
Nora Au, Elke Kuester-Schoeck, Veena Mandava, Laura E Bothwell, Susan P Canny, Karen Chachu, Sierra A Colavito, Shakierah N Fuller, Eli S Groban, Laura A Hensley, Theresa C O'Brien, Amish Shah, Jessica T Tierney, Louise L Tomm, Thomas M O'Gara, Alexi I Goranov, Alan D Grossman, Charles M Lovett
Genetic composition of the Bacillus subtilis SOS system.
J Bacteriol: 2005, 187(22);7655-66
[PubMed:16267290]
[WorldCat.org]
[DOI]
(P p)
Tung-Ju Hsieh, Lynn Farh, Wai Mun Huang, Nei-Li Chan
Structure of the topoisomerase IV C-terminal domain: a broken beta-propeller implies a role as geometry facilitator in catalysis.
J Biol Chem: 2004, 279(53);55587-93
[PubMed:15466871]
[WorldCat.org]
[DOI]
(P p)