Difference between revisions of "SodA"

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* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2RCV 2RCV]
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2RCV 2RCV]
  
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P54375 P54375]
+
* '''UniProt:''' [http://www.uniprot.org/uniprot/P54375 P54375]
  
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25020]
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU25020]

Revision as of 13:37, 20 July 2009

  • Description: superoxide dismutase, general stress protein

Gene name sodA
Synonyms yqgD
Essential no
Product superoxide dismutase
Function detoxification of oxygen radicals
MW, pI 22 kDa, 5.203
Gene length, protein length 606 bp, 202 aa
Immediate neighbours yqgE, yqgC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SodA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU25020

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 superoxide + 2 H+ = O2 + H2O2 (according to Swiss-Prot)
  • Protein family: iron/manganese superoxide dismutase family (according to Swiss-Prot)
  • Paralogous protein(s): SodF

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Thr-34 AND Thr-70 PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

A O Henriques, L R Melsen, C P Moran
Involvement of superoxide dismutase in spore coat assembly in Bacillus subtilis.
J Bacteriol: 1998, 180(9);2285-91
[PubMed:9573176] [WorldCat.org] [DOI] (P p)

L Casillas-Martinez, P Setlow
Alkyl hydroperoxide reductase, catalase, MrgA, and superoxide dismutase are not involved in resistance of Bacillus subtilis spores to heat or oxidizing agents.
J Bacteriol: 1997, 179(23);7420-5
[PubMed:9393707] [WorldCat.org] [DOI] (P p)