Smc - Revision history

Jstuelk: /* Original publications */

2015-08-24T08:52:19Z

‎Original publications

Jstuelk: /* Original publications */

2015-08-10T08:32:54Z

‎Original publications

Jstuelk: /* Original publications */

2015-05-08T07:57:40Z

‎Original publications

Jstuelk at 16:16, 26 April 2015

2015-04-26T16:16:06Z

Jstuelk: /* Original publications */

2015-02-11T12:20:18Z

‎Original publications

Jstuelk at 17:09, 10 February 2015

2015-02-10T17:09:51Z

Jstuelk: /* Original publications */

2015-02-08T17:37:53Z

‎Original publications

Jstuelk: /* Original publications */

2014-07-30T11:35:15Z

‎Original publications

Jstuelk: /* Reviews */

2014-05-23T15:28:16Z

‎Reviews

134.76.70.252 at 11:46, 8 April 2014

2014-04-08T11:46:33Z

← Older revision		Revision as of 08:52, 24 August 2015
Line 1:		Line 1:
−	* '''Description:~~''' part of the [[condensin]] complex, chromosomal origin condensation and segregation SMC protein <br/><br/>~~	+	{{#bank: Smc}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''smc''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| ''ylqA ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| yes {{PubMed\|24440399,12682299}}~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| chromosome condensation and segregation SMC protein~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| segregation of replication origins~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940 smc]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Smc Smc]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Metabolic function and regulation of this protein in [[SubtiPathways\|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=Smc Smc]'''
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 135 kDa, 5.266~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 3558 bp, 1186 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[rnc]]'', ''[[ftsY]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU15940 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU15940 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU15940 DNA_with_flanks]
−	\|-
−	\|-
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:smc_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=smc_1666560_1670120_1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:smc_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15940]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[DNA condensation/ segregation]]}},~~
−	~~{{SubtiWiki category\|[[essential genes]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU15940
−
−	~~===Phenotypes of a mutant ===~~
−	* essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
−	* ''[[smc]]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth {{PubMed\|24440399,24440393}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15940&redirect=T BSU15940]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rnc-smc-ftsY.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11538]
−
−	~~=== Additional information===~~
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−
−	* '''Protein family:''' SMC family (according to Swiss-Prot)
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''[[Domains]]:'''
−
−	* '''Modification:'''
−
−	* '''[[Cofactors]]:'''
−
−	* '''Effectors of protein activity:'''
−	** ATP-induced DNA-binding results in a more open conformation of the [[Smc]] dimer, and thus of the [[condension]] complex {{PubMed\|25557547}}
−
−	* '''[[SubtInteract\|Interactions]]:'''
−	** part of the [[condensin]] complex {{PubMed\|24440399,24440393}}
−	** forms dimers {{PubMed\|22385855}}
−	** [[ScpA]]-[[Smc]] {{PubMed\|12100548}}
−	** [[ScpB]]-[[Smc]], {{PubMed\|22385855,12100548,12421306}}, this interaction takes place only in the presence of [[ScpA]] {{PubMed\|22385855}}
−	** [[Smc]] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [[SubtInteract\|interactions]] {{PubMed\|21630458}}
−
−	* '''[[Localization]]:'''
−	** nucleoid (heterogeneous) {{PubMed\|16479537}}
−	** the [[condensin]] ([[Smc]])2-[[ScpA]]-[[ScpB]] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [[Spo0J]] {{PubMed\|24440393,23475963}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15940&redirect=T BSU15940]
−
−	* '''Structure:'''
−	** [http://www.pdb.org/pdb/explore/explore.do?structureId=3ZGX 3ZGX] (complex between the head domain of [[Smc]] (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of [[ScpA]]) {{PubMed\|23353789}}
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/P51834 P51834]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU15940]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' ''[[rnc]]-[[smc]]-[[ftsY]]'' {{PubMed\|11021934}}
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=smc_1666560_1670120_1 smc] {{PubMed\|22383849}}
−
−	* '''[[Sigma factor]]:''' [[SigA]] {{PubMed\|11021934}}
−
−	* '''Regulation:'''
−
−	* '''Regulatory mechanism:'''
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−	** 1A822 ( ''smc''::''erm''), {{PubMed\|12682299}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A822&Search=1A822 BGSC]
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−	~~==Reviews==~~
−	~~<pubmed>19308706 22934648 22047950 22933559 24118085 </pubmed>~~
−
−	~~==Original publications==~~
−	<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 25951515 26253537 24440399,24440393 23475963 25557547 25664627</pubmed>
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 155: / Line 155: @@
 ==Original publications==
-<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 25951515 24440399,24440393 23475963 25557547 25664627</pubmed>
+<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 25951515 26253537 24440399,24440393 23475963 25557547 25664627</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 155: / Line 155: @@
 ==Original publications==
-<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 24440399,24440393 23475963 25557547 25664627</pubmed>
+<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 25951515 24440399,24440393 23475963 25557547 25664627</pubmed>
 [[Category:Protein-coding genes]]

← Older revision		Revision as of 16:16, 26 April 2015
Line 90:		Line 90:

	* '''Effectors of protein activity:'''		* '''Effectors of protein activity:'''
		+	** ATP-induced DNA-binding results in a more open conformation of the [[Smc]] dimer, and thus of the [[condension]] complex {{PubMed\|25557547}}

	* '''[[SubtInteract\|Interactions]]:'''		* '''[[SubtInteract\|Interactions]]:'''

@@ Line 154: / Line 154: @@
 ==Original publications==
-<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 24440399,24440393 23475963 25557547 </pubmed>
+<pubmed>9791128,12100548,17416649,19450516,12421306,11395470, 19450517, 19450516 15009890 16479537 21630458 23353789 25071173 22385855 24440399,24440393 23475963 25557547 25664627</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 8: / Line 8: @@
 |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ylqA ''
 |-
-|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
+|style="background:#ABCDEF;" align="center"| '''Essential''' || yes {{PubMed|24440399,12682299}}
 |-
 |style="background:#ABCDEF;" align="center"| '''Product''' || chromosome condensation and segregation SMC protein

@@ Line 151: / Line 151: @@
 =References=
 ==Reviews==
-<pubmed>19308706 22934648 22047950 22933559 </pubmed>
+<pubmed>19308706 22934648 22047950 22933559 24118085 </pubmed>
 ==Original publications==

@@ Line 18: / Line 18: @@
 |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=Smc Smc]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in  [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=Smc Smc]'''
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 135 kDa, 5.266