PfeT - Revision history

Jstuelk at 13:30, 13 August 2015

2015-08-13T13:30:24Z

Jstuelk: /* Categories containing this gene/protein */

2015-08-12T11:07:16Z

‎Categories containing this gene/protein

Jstuelk at 09:09, 12 August 2015

2015-08-12T09:09:00Z

Jstuelk at 08:58, 12 August 2015

2015-08-12T08:58:26Z

Jstuelk at 08:30, 12 August 2015

2015-08-12T08:30:36Z

Jstuelk: Jstuelk moved page ZosA to PfeT: 26261021

2015-08-12T08:28:37Z

Jstuelk moved page ZosA to PfeT: 26261021

134.76.70.252 at 11:53, 8 April 2014

2014-04-08T11:53:28Z

134.76.38.147 at 13:33, 2 April 2014

2014-04-02T13:33:47Z

134.76.70.252 at 13:07, 16 May 2013

2013-05-16T13:07:46Z

134.76.70.252 at 10:03, 14 May 2013

2013-05-14T10:03:42Z

← Older revision		Revision as of 13:30, 13 August 2015
Line 1:		Line 1:
−	* '''Description:~~''' Fe(II) efflux pump, P1B4 -type ATPase, protects the cell against iron intoxication<br/><br/>~~	+	{{#bank: PfeT}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''zosA''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| ''ykvW''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| Fe(II) efflux pump~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| protection against toxic iron~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13850 pfeT]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Metabolic function and regulation of this protein in [[SubtiPathways\|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=PfeT PfeT]'''
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 68 kDa, 4.934~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 1911 bp, 637 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[stoA]]'', ''[[papB]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13850 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13850 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13850 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:ykvW_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=zosA_1451371_1453284_1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:zosA_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13850]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[transporters/ other]]}},~~
−	~~{{SubtiWiki category\|[[iron metabolism]]}},~~
−	~~{{SubtiWiki category\|[[membrane proteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[PerR regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU13850
−
−	~~===Phenotypes of a mutant ===~~
−	** sensitivity to iron, this can be suppressed by low levels of Mn(II) {{PubMed\|26261021}}
−	** reduced genetic competence, can be rescued by the addition of excess zinc {{PubMed\|21813502}}
−	** reduced expression of ''[[comK]]'', control is exerted at the post-transcriptional level and can be rescued by the addition of excess zinc {{PubMed\|21813502}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13850&redirect=T BSU13850]
−
−	* '''DBTBS entry:''' no entry
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13325]
−
−	~~=== Additional information===~~
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:''' ATP + H<sub>2</sub>O + Zn<sup>2+</sup>(In) = ADP + phosphate + Zn<sup>2+</sup>(Out) (according to Swiss-Prot) P-type zinc-transporting ATPase [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
−
−	* '''Protein family:''' Type IB subfamily (according to Swiss-Prot)
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''Domains:'''
−
−	* '''Modification:'''
−
−	* '''Cofactor(s):'''
−
−	* '''Effectors of protein activity:'''
−
−	* '''[[SubtInteract\|Interactions]]:'''
−
−	* '''[[Localization]]:''' cell membrane (according to Swiss-Prot)
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU13850&redirect=T BSU13850]
−
−	* '''Structure:'''
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/O31688 O31688]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU13850]
−
−	* '''E.C. number:''' [http://www.expasy.org/enzyme/3.6.3.5 3.6.3.5]
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' ''pfeT'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=zosA_1451371_1453284_1 pfeT] {{PubMed\|22383849}}
−
−	* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
−
−	* '''Regulation:''' induced by hydrogen peroxide ([[PerR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
−
−	* '''Regulatory mechanism:'''
−	** [[PerR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
−
−	* '''Additional information:'''
−	** A [[ncRNA]] is predicted between ''[[stoA]]'' and ''[[zosA]]'' {{PubMed\|20525796}}
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−
−	~~<pubmed>14563870,12426338,12486061,12180919,12779235, 21813502,12180919,12180919, 20525796 26261021</pubmed>~~
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 41: / Line 41: @@
 = [[Categories]] containing this gene/protein =
 {{SubtiWiki category|[[transporters/ other]]}},
-{{SubtiWiki category|[[trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]]}},
+{{SubtiWiki category|[[iron metabolism]]}},
 {{SubtiWiki category|[[membrane proteins]]}}

@@ Line 54: / Line 54: @@
 ===Phenotypes of a mutant ===
 ** reduced genetic competence, can be rescued by the addition of excess zinc {{PubMed|21813502}}
 ** reduced expression of ''[[comK]]'', control is exerted at the post-transcriptional level and can be rescued by the addition of excess zinc  {{PubMed|21813502}}

@@ Line 1: / Line 1: @@
-* '''Description:''' P1B4 -type ATPase, effluxes ferrous iron and protects the cell against iron intoxication<br/><br/>
+* '''Description:''' Fe(II) efflux pump, P1B4 -type ATPase, protects the cell against iron intoxication<br/><br/>
 {| align="right" border="1" cellpadding="2"
@@ Line 10: / Line 10: @@
 |style="background:#ABCDEF;" align="center"| '''Essential''' || no
 |-
-|style="background:#ABCDEF;" align="center"| '''Product''' || P-type iron-exporting ATPase
+|style="background:#ABCDEF;" align="center"| '''Product''' || Fe(II) efflux pump
 |-
 |style="background:#ABCDEF;" align="center"|'''Function''' || protection against toxic iron
@@ Line 108: / Line 108: @@
 =Expression and regulation=
-* '''Operon:''' ''zosA'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
+* '''Operon:''' ''pfeT'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]
-* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=zosA_1451371_1453284_1 zosA] {{PubMed|22383849}}
+* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=zosA_1451371_1453284_1 pfeT] {{PubMed|22383849}}
 * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12180919 PubMed]

@@ Line 1: / Line 1: @@
-* '''Description:''' zinc transporter<br/><br/>
+* '''Description:''' P1B4 -type ATPase, effluxes ferrous iron and protects the cell against iron intoxication<br/><br/>
 {| align="right" border="1" cellpadding="2"
@@ Line 10: / Line 10: @@
 |style="background:#ABCDEF;" align="center"| '''Essential''' || no
 |-
-|style="background:#ABCDEF;" align="center"| '''Product''' || P-type zinc-transporting ATPase
+|style="background:#ABCDEF;" align="center"| '''Product''' || P-type iron-exporting ATPase
 |-
-|style="background:#ABCDEF;" align="center"|'''Function''' || zinc uptake
+|style="background:#ABCDEF;" align="center"|'''Function''' || protection against toxic iron
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13850 zosA]
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13850 pfeT]
 |-
-|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=ZosA ZosA]'''
+|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=PfeT PfeT]'''
 |-
 |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 68 kDa, 4.934
@@ Line 142: / Line 142: @@
 =References=
-<pubmed>14563870,12426338,12486061,12180919,12779235, 21813502,12180919,12180919, 20525796</pubmed>
+<pubmed>14563870,12426338,12486061,12180919,12779235, 21813502,12180919,12180919, 20525796 26261021</pubmed>
 [[Category:Protein-coding genes]]

← Older revision	Revision as of 08:28, 12 August 2015
(No difference)

@@ Line 56: / Line 56: @@
 === Database entries ===
 * '''DBTBS entry:''' no entry
@@ Line 91: / Line 92: @@
 === Database entries ===
 * '''Structure:'''

@@ Line 27: / Line 27: @@
   <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 |-
-|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=zosA_1451371_1453284_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:zosA_expression.png|500px]]
+|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=zosA_1451371_1453284_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:zosA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13850]]
 |-
 |}

@@ Line 22: / Line 22: @@
 |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[stoA]]'', ''[[papB]]''
 |-
-|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13850 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13850 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13850 Advanced_DNA]
+|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13850 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13850 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13850 DNA_with_flanks]
 |-
 |colspan="2" | '''Genetic context''' <br/> [[Image:ykvW_context.gif]]