Papers of the month - Revision history

Jstuelk: /* 2026 */

2026-05-28T11:21:36Z

‎2026

2026-05-28T11:20:44Z

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2026-05-28T11:01:07Z

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2026-05-28T10:58:09Z

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2026-03-01T17:00:19Z

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2026-02-17T13:55:25Z

2026-02-17T13:39:46Z

‎2025

2026-02-17T13:34:03Z

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2025-10-27T16:09:04Z

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2025-08-28T13:30:57Z

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 * '''April 2026'''
 ** The ''B. subtilis'' [[AcuB]] protein controls [[AcuC]] deacetylase activity and thus the activity of the acetyl-CoA synthetase [[AcsA]]. Recently (see POTM for February 2026), Ap4A was identified as an effector molecule for [[AcuB]]. Now, [https://www.nature.com/articles/s41467-026-71006-w Janetzky et al.] from the lab of [[Michael Lammers]] reveal that AMP also controls [[AcuB]] activity. Given the cellular concentrations of both metabolite, AMP is likely to be the physiologically relevant effector molecule.
-** '''Relevant ''Subti''Wiki pages:''' [[AcuB]], [[AcuC]], [[AcsA]] [[Michael Lammers]]
+** '''Relevant ''Subti''Wiki pages:''' [[AcuB]], [[AcuC]], [[AcsA]], [[Michael Lammers]]
 <pubmed>42031755</pubmed>

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 ** '''Relevant ''Subti''Wiki pages:''' [[GltA]], [[GltB]], [[RocG]] [[GudB]], [[GltC]], [[TnrA]], [[GlnR]], [[GlnA]], [[Fabian Commichau]]
 <pubmed>42126227</pubmed>
 * '''February 2026'''

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 ** Many proteins have more than one activity, and these multiple function cam also be physiologically relevant. Now, [https://journals.asm.org/doi/10.1128/mmbr.00430-25 Gibhardt et al.] from the lab of [[Fabian Commichau]] review the multiple roles of moonlighting proteins in nitrogen metabolism in ''B. subtilis''.
 ** '''Relevant ''Subti''Wiki pages:''' [[GltA]], [[GltB]], [[RocG]] [[GudB]], [[GltC]], [[TnrA]], [[GlnR]], [[GlnA]], [[Fabian Commichau]]
-<pubmed>41730913</pubmed>
+<pubmed>42126227</pubmed>
 * '''February 2026'''

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 * '''February 2026'''
 ** Ap4A has been identified as a novel second messenger; however, little is known on its function(s) and interaction(s). Now, [https://www.nature.com/articles/s41467-026-70006-0 Zheng et al.] have identified the AcuB protein as a target of Ap4A. [[AcuB]] interacts with and inhibits the deacetylase activity of [[AcuC]]. Ap4A binds to the CBS domains of [[AcuB]] resulting in the stabilization of the protein.

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 =2026=
 * '''February 2026'''
 ** Cell division is finalized with separation and the separation of the daughter cells. Now, [https://www.nature.com/articles/s41467-026-69404-1 Patel et al.] have discovered a previously unrecognized, post-septational wave of transpeptidation that crosslinks septal peptidoglycan during cell separation in ''B. subtilis''. The work expands the current model of cell division by identifying post-septational transpeptidation as a key step in septal resolution and pole formation.
-** '''Relevant ''Subti''Wiki pages:''' [[cell division]], [[PbpH]], [[LytF]
+** '''Relevant ''Subti''Wiki pages:''' [[cell division]], [[PbpH]], [[LytF]]
-<pubmed>41680165</pubmed>
+<pubmed>41680165</pubmed
 =2025=

← Older revision		Revision as of 13:55, 17 February 2026
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		+	=2026=
		+	* '''February 2026'''
		+	** Cell division is finalized with separation and the separation of the daughter cells. Now, [https://www.nature.com/articles/s41467-026-69404-1 Patel et al.] have discovered a previously unrecognized, post-septational wave of transpeptidation that crosslinks septal peptidoglycan during cell separation in ''B. subtilis''. The work expands the current model of cell division by identifying post-septational transpeptidation as a key step in septal resolution and pole formation.
		+	** '''Relevant ''Subti''Wiki pages:''' [[cell division]], [[PbpH]], [[LytF]
		+	<pubmed>41680165</pubmed>
		+
		+
	=2025=		=2025=
	* '''December 2025'''		* '''December 2025'''

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 * '''December 2025'''
 ** Even though sporulation has been intensively studied for more than a century, there are still sporulation genes without an established function. Now, [https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003521 Ramírez-Guadiana et al.] from the lab of [[David Rudner]] used transposon-sequencing to identify a comprehensive set of sporulation genes in ''Bacillus anthracis''. To validate and characterize their hits, they constructed an ordered transposon-mutant library. They found that many sporulation factors function similarly in pathogen and model, but key differences were also identified, informing the functions of homologous ''B. subtilis'' proteins.
-** '''Relevant ''Subti''Wiki pages:''' [[David Rudner]], [[YheN]], [[YkyA]]
+** '''Relevant ''Subti''Wiki pages:''' [[David Rudner]], [[YheN|PdaN]], [[YkyA|PdcF]]
-<pubmed>41045937</pubmed>
+<pubmed>41385520</pubmed>
 * '''October 2025'''

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 * '''August 2025'''
 ** Complex redox chains often have to connect various metabolic pathways that can be in distinct cellular compartments. Now,[https://www.nature.com/articles/s41594-025-01607-4 Broc et al.] uncovered a structural module that enables channeling of quinones from the membrane to various water-soluble redox catalytic units in prokaryotes. They identify a '''helical membrane plugin''' that links formate and NAHD oxidation in ''B. subtilis'' to the respiratory chain.

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 =2025=
 * '''July 2025'''
 ** The mechanism of lateral cell-wall expansion during growth has not yet been identified for ''B. subtilis''. Now,[https://www.nature.com/articles/s41467-025-61900-0 Liang et al.] use cell imaging and mass spectrometry analysis of isotopically labeled peptidoglycan to study this process. They show that new glycan strands are cross-linked exclusively to other newly synthesized glycan chains, and not to the existing peptidoglycan network. They suggest that new peptidoglycan meshes, assembled at the membrane surface, impose a shift on older meshes toward the bacterial surface, where they sustain the cytoplasmic turgor pressure, before their eventual degradation. This outward movement would result in preferential lateral expansion due to the large difference in the strain tensors of the peptidic and glycosidic peptidoglycan components.