KinC - Revision history

Jstuelk at 15:41, 28 August 2015

2015-08-28T15:41:46Z

Atkovacs at 11:13, 23 July 2015

2015-07-23T11:13:43Z

Jstuelk: /* Original publications */

2015-07-13T14:06:17Z

‎Original publications

Jstuelk: /* Reviews */

2015-05-04T09:33:01Z

‎Reviews

Jstuelk: /* Original publications */

2015-02-24T09:01:31Z

‎Original publications

Jstuelk: /* Original publications */

2015-02-23T17:02:52Z

‎Original publications

Jstuelk at 17:02, 23 February 2015

2015-02-23T17:02:26Z

Jstuelk: /* References */

2015-02-20T12:17:21Z

‎References

Jstuelk: /* Extended information on the protein */

2014-10-27T16:14:42Z

‎Extended information on the protein

134.76.38.147 at 13:36, 2 April 2014

2014-04-02T13:36:21Z

← Older revision		Revision as of 15:41, 28 August 2015
Line 1:		Line 1:
−	* '''Description:''' [[two-component systems\|two-component]] sensor kinase, phosphorylates [[Spo0F]] and [[Spo0A]], part of the [[phosphorelay]], governs expression of genes involved in [[biofilm formation]] <br/><br/>	+	{{#bank: KinC}}

−	~~{\| align="right" border="1" cellpadding="2"~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Gene name'''~~
−	~~\|''kinC''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Synonyms''' \|\| ''ssb ''~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Essential''' \|\| no~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Product''' \|\| [[two-component systems\|two-component]] sensor kinase~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Function''' \|\| initiation of [[sporulation]]~~
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14490 kinC]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=KinC KinC]
−	\|-
−	\|colspan="2" style="background:#FAF8CC;" align="center"\| '''Function and regulation of this protein in [[SubtiPathways\|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=kinC kinC]'''
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''MW, pI''' \|\| 48 kDa, 6.225~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\| '''Gene length, protein length''' \|\| 1284 bp, 428 aa~~
−	\|-
−	~~\|style="background:#ABCDEF;" align="center"\|'''Immediate neighbours''' \|\| ''[[abh]]'', ''[[ykqA]]''~~
−	\|-
−	\|style="background:#FAF8CC;" align="center"\|'''Sequences'''\|\|[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14490 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14490 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14490 DNA_with_flanks]
−	\|-
−	~~\|colspan="2" \| '''Genetic context''' <br/> [[Image:kinC_context.gif]]~~
−	~~<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>~~
−	\|-
−	\|colspan="2" \|'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinC_1518333_1519619_1 Expression at a glance]'''   {{PubMed\|22383849}}<br/>[[Image:kinC_expression.png\|500px\|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14490]]
−	\|-
−	\|}
−
−	~~__TOC__~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/><br/><br/>~~
−	~~<br/><br/>~~
−
−	~~= [[Categories]] containing this gene/protein =~~
−	~~{{SubtiWiki category\|[[protein modification]]}},~~
−	~~{{SubtiWiki category\|[[transcription factors and their control]]}},~~
−	~~{{SubtiWiki category\|[[phosphorelay]]}},~~
−	~~{{SubtiWiki category\|[[biofilm formation]]}},~~
−	~~{{SubtiWiki category\|[[membrane proteins]]}},~~
−	~~{{SubtiWiki category\|[[phosphoproteins]]}}~~
−
−	~~= This gene is a member of the following [[regulons]] =~~
−	~~{{SubtiWiki regulon\|[[Spo0A regulon]]}}~~
−
−	~~=The gene=~~
−
−	~~=== Basic information ===~~
−
−	* '''Locus tag:''' BSU14490
−
−	~~===Phenotypes of a mutant ===~~
−	** defective in [[biofilm formation]] {{PubMed\|22882210}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14490&redirect=T BSU14490]
−
−	* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/kinC.html]
−
−	* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10989]
−
−	~~=== Additional information===~~
−
−
−	~~=The protein=~~
−
−	~~=== Basic information/ Evolution ===~~
−
−	* '''Catalyzed reaction/ biological activity:'''
−	** autophosphorylation, phosphorylation of [[Spo0F]] as part of the [[phosphorelay]], but also direct phosphorylation of [[Spo0A]] {{PubMed\|19114652}}
−	** mainly active in the younger, outer regions of a colony (with [[KinD]]) {{PubMed\|21097618}}
−	** phosphorylates [[Spo0A]] in response to the presence of surfactin {{PubMed\|22882210}}, this has been refuted {{PubMed\|25701730}}
−	** required for initiation of [[sliding]] together with [[KinB]] {{PubMed\|26152584}}
−
−	* '''Protein family:'''
−
−	* '''Paralogous protein(s):'''
−
−	~~=== Extended information on the protein ===~~
−
−	* '''Kinetic information:'''
−
−	* '''[[Domains]]:'''
−	** two transmembrane segments
−	** [[PAS domain]]
−	** C-terminal histidine phosphotransferase domain
−
−	* '''Modification:''' autophosphorylation on a His residue
−
−	* '''Cofactor(s):'''
−
−	* '''Effectors of protein activity:'''
−	** activity is triggered by potassium leakage {{PubMed\|19114652}}, this has been refuted {{PubMed\|25701730}}
−	** activity is triggered by polyisoprenoid lipids formed by [[YisP]] {{PubMed\|20713508}}
−
−	* '''[[SubtInteract\|Interactions]]:'''
−	** [[KinC]]-[[Spo0A]] {{PubMed\|19114652}}
−	** [[KinC]]-[[Spo0F]]
−
−	* '''[[Localization]]:'''
−	** cell membrane (Heterogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
−	** co-localizes with [[FloT]] in discrete foci in the membrane {{PubMed\|20713508}}
−	** the localization of [[KinC]] in membrane microdomains depends on [[FloA]] and [[FloT]] {{PubMed\|22882210}}, this has been refuted {{PubMed\|25701730}}
−
−	~~=== Database entries ===~~
−	* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU14490&redirect=T BSU14490]
−
−	* '''Structure:'''
−
−	* '''UniProt:''' [http://www.uniprot.org/uniprot/P39764 P39764]
−
−	* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU14490]
−
−	* '''E.C. number:'''
−
−	~~=== Additional information===~~
−
−	~~=Expression and regulation=~~
−
−	* '''Operon:''' kinC (according to [http://dbtbs.hgc.jp/COG/prom/kinC.html DBTBS])
−
−	* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=kinC_1518333_1519619_1 kinC] {{PubMed\|22383849}}
−
−	* '''Sigma factor:''' [[SigA]] {{PubMed\|8002614}}
−
−	* '''Regulation:'''
−	** expressed under conditions that trigger sporulation ([[Spo0A]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8002615 PubMed]
−
−	* '''Regulatory mechanism:'''
−	** [[Spo0A]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8002615 PubMed]
−
−	* '''Additional information:'''
−
−	~~=Biological materials =~~
−
−	* '''Mutant:'''
−	** 1A632 ( ''kinC''::''erm''), {{PubMed\|3015878}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A632&Search=1A632 BGSC]
−	** BAL393 (''kinC''::''spc''){{PubMed\|26152584}}
−
−	* '''Expression vector:'''
−
−	* '''lacZ fusion:'''
−
−	* '''GFP fusion:'''
−
−	* '''two-hybrid system:'''
−
−	* '''Antibody:'''
−
−	~~=Labs working on this gene/protein=~~
−
−	~~=Your additional remarks=~~
−
−	~~=References=~~
−	~~== Reviews ==~~
−	~~<pubmed>25934647 25652542</pubmed>~~
−
−	~~== Original publications ==~~
−	~~<pubmed>26152584,19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730 26152584</pubmed>~~
−
−	~~[[Category:Protein-coding genes]]~~

@@ Line 79: / Line 79: @@
 ** mainly active in the younger, outer regions of a colony (with [[KinD]]) {{PubMed|21097618}}
 ** phosphorylates [[Spo0A]] in response to the presence of surfactin {{PubMed|22882210}}, this has been refuted {{PubMed|25701730}}
 * '''Protein family:'''
@@ Line 143: / Line 144: @@
 * '''Mutant:'''
 ** 1A632 ( ''kinC''::''erm''), {{PubMed|3015878}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A632&Search=1A632 BGSC]
 * '''Expression vector:'''
@@ Line 163: / Line 165: @@
 == Original publications ==
-<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730 26152584</pubmed>
+<pubmed>26152584,19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730 26152584</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 163: / Line 163: @@
 == Original publications ==
-<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730</pubmed>
+<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730 26152584</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 160: / Line 160: @@
 =References=
 == Reviews ==
-<pubmed> 25652542</pubmed>
+<pubmed>25934647 25652542</pubmed>
 == Original publications ==
 <pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 162: / Line 162: @@
 <pubmed> 25652542</pubmed>
 == Original publications ==
-<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765  25701730 </pubmed>
+<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 1: / Line 1: @@
-* '''Description:''' [[two-component systems|two-component]] sensor kinase, phosphorylates [[Spo0F]] and [[Spo0A]] in response to the presence of surfactin, part of the [[phosphorelay]], governs expression of genes involved in [[biofilm formation]] <br/><br/>
+* '''Description:''' [[two-component systems|two-component]] sensor kinase, phosphorylates [[Spo0F]] and [[Spo0A]], part of the [[phosphorelay]], governs expression of genes involved in [[biofilm formation]] <br/><br/>
 {| align="right" border="1" cellpadding="2"
@@ Line 39: / Line 39: @@
 <br/><br/><br/><br/>
 <br/><br/><br/><br/>
 <br/><br/>
 = [[Categories]] containing this gene/protein =
@@ Line 79: / Line 78: @@
 ** autophosphorylation, phosphorylation of [[Spo0F]] as part of the [[phosphorelay]], but also direct phosphorylation of [[Spo0A]] {{PubMed|19114652}}
 ** mainly active in the younger, outer regions of a colony (with [[KinD]]) {{PubMed|21097618}}
-** phosphorylates [[Spo0A]] in response to the presence of surfactin {{PubMed|22882210}}
+** phosphorylates [[Spo0A]] in response to the presence of surfactin {{PubMed|22882210}}, this has been refuted {{PubMed|25701730}}
 * '''Protein family:'''
@@ Line 99: / Line 98: @@
 * '''Effectors of protein activity:'''
-** activity is triggered by potassium leakage {{PubMed|19114652}}
+** activity is triggered by potassium leakage {{PubMed|19114652}}, this has been refuted {{PubMed|25701730}}
 ** activity is triggered by polyisoprenoid lipids formed by [[YisP]] {{PubMed|20713508}}
@@ Line 109: / Line 108: @@
 ** cell membrane (Heterogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
 ** co-localizes with [[FloT]] in discrete foci in the membrane {{PubMed|20713508}}
-** the localization of [[KinC]] in membrane microdomains depends on [[FloA]] and [[FloT]]  {{PubMed|22882210}}
+** the localization of [[KinC]] in membrane microdomains depends on [[FloA]] and [[FloT]]  {{PubMed|22882210}}, this has been refuted {{PubMed|25701730}}
 === Database entries ===
@@ Line 163: / Line 162: @@
 <pubmed> 25652542</pubmed>
 == Original publications ==
-<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 </pubmed>
+<pubmed>19114652,10094672,11069677,16166384, 20713508,8002615, 16479537 8002614 20946851 20971918 21097618 22882210 23927765 25701730</pubmed>
 [[Category:Protein-coding genes]]

@@ Line 89: / Line 89: @@
 * '''Kinetic information:'''
-* '''Domains:''' two transmembrane segments, C-terminal histidine phosphotransferase domain
+* '''[[Domains]]:'''
 * '''Modification:''' autophosphorylation on a His residue
@@ Line 106: / Line 109: @@
 ** cell membrane (Heterogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
 ** co-localizes with [[FloT]] in discrete foci in the membrane {{PubMed|20713508}}
 ** the localization of [[KinC]] in membrane microdomains depends on [[FloA]] and [[FloT]]  {{PubMed|22882210}}
 === Database entries ===

@@ Line 63: / Line 63: @@
 === Database entries ===
 * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/kinC.html]
@@ Line 108: / Line 109: @@
 === Database entries ===
 * '''Structure:'''